PROGRAMS IN BIOMEDICAL ENGINEERING

204 Rockwell Engineering Center; (949) 824-4051
Steven C. George, Director

Undergraduate Program

Graduate Program

Courses

Faculty

Guillermo Aguilar-Mendoza: Experimental and numerical modeling of fluid mechanics, and thermal processes taking part in biomedical optics and medical laser applications

Nancy Allbritton: Intracellular signaling and biophysical optics

Pierre Baldi: Bioinformatics/computational biology and probabilistic modeling/machine learning

Michael W. Berns: Photomedicine, laser microscopy, biomedical devices

Lubomir Bic: Distributed computing, parallel processing in biological systems

Bruce Blumberg: Biorobotics, functional genomics

James P. Brody: Bioinformatics, micro-nanoscale systems

Jay W. Calvert: Tissue engineering

Ying-Chih Chang: Molecular engineering, polymer chemistry, biomaterials, interfacial phenomena

Zhongping Chen: Biomedical optics, optical coherence tomography, bioMEMS, and biomedical devices

Zang-Hee Cho: Multidimensional imaging; NMR tomography and positron emission tomography

Carl Cotman: Computational methods in brain aging, Alzheimer's disease

Rui J. P. de Figueiredo: Biomedical signal and image processing and analysis

James Earthman: Biomaterials, dental, and orthopaedic implants

Gregory Evans: Tissue engineering

Ron Frostig: Optical methods for brain imaging, functional organization of the cortex

Steven C. George: Physiological modeling, gas exchange, computational methods, tissue engineering

Steven Gross: In-vivo function of molecular motors, optical tweezers

Ranjan Gupta: In-vivo models for chronic nerve injury

Noo Li Jeon: Soft lithography in fabricating devices

Ghassan Kassab: Vascular networks, coronary circulation in health disease, tissue remodeling, simulation of complex biological systems.

Joyce Keyak: Bone mechanics, finite element modeling, computed tomography

Richard Lathrop: Computational methods in protein engineering

Enrique Lavernia: Kinetic processes in materials, dermatology applications, mechanical analysis of cartilage

Abraham Lee: Microelectromechanical Systems (MEMS), microfluidics, catheter-based microsurgical devices, microactuators for medical and optical applications, microfabrication processes.

Thay Lee: Orthopaedic biomechanics

Guann Pyng Li: Microelectromechanical systems for biomedical applications

Shin Lin: The combined use of biochemistry, cell biology, molecular biology, and molecular biophysics to study the structure and function of proteins involved in cytoskeletal/contractile functions and signal transduction in muscle and nonmuscle cells.

John Longhurst: Research in cardiovascular neural reflex control mechanisms from somatic and visceral regions including the heart and abdominal organs; integrative, central neural regulation of the autonomic outflow, with reference to cardiovascular reflex responses and including the reflex basis of acupuncture.

Sabee Molloi: Digital radiography, application of digital subtraction angiography to cardiac imaging, coronary artery flow measurement, digital image processing

J. Stuart Nelson: Phototherapy, dermatology, cell biology, biomedical device development

Qing Nie: Computational applied mathematics

David Reinkensmeyer: Skeletal muscle control, biorobotics, rehabilitation

Phillip C.-Y. Sheu: Biomedical database management, Intranet/Internet technologies

Andrei Shkel: Silicon integrated Micro-Electro-Mechanical Sensors and Actuators

Harry Skinner: Orthopaedic implant devices, minimally invasive surgical systems

Padhraic Smyth: Applied statistics, pattern recognition, and data mining with applications to time-series and image data

Michael Sundine: Tissue engineering

Bruce Tromberg: Photon migration, biophysics, optical microscopy, fiber-optic sensors

Vasan Venugopalan: Application of laser radiation for medical diagnostics, therapeutics, and biotechnology; laser-induced thermal, mechanical, and radiative transport processes

Brian Wong: Biomedical optics, tissue engineering, and development of surgical instrumentation

Fan-Gang Zeng: Cochlear implants and auditory neuroscience

Participating faculty are from the Schools of Biological Sciences and Physical Sciences, The Henry Samueli School of Engineering, the College of Medicine, and the Department of Information and Computer Science.

Biomedical engineering combines engineering expertise with medical needs for the enhancement of health care. It is a branch of engineering in which knowledge and skills are developed and applied to define and solve problems in biology and medicine. Students choose the biomedical engineering field to be of service to people, for the excitement of working with living systems, and to apply advanced technology to the complex problems of medical care. Biomedical engineers may be called upon to design instruments and devices, to bring together knowledge from many sources to develop new procedures, or to carry out research to acquire knowledge needed to solve new problems.

During the last 20 years, we have witnessed unprecedented advances in engineering, medical care, and the life sciences. The combination of exploding knowledge and technology in biology, medicine, the physical sciences, and engineering, coupled with the changes in the way health care will be delivered in the next century, provide a fertile ground for biomedical engineering. Biomedical engineering, at the confluence of these fields, has played a vital role in this progress. Traditionally, engineers have been concerned with inanimate materials, devices, and systems, while life scientists have investigated biological structure and function. Biomedical engineers integrate these disciplines in a unique way, combining the methodologies of the physical sciences and engineering with the study of biological and medical problems. The collaboration between engineers, physicians, biologists, and physical scientists is an integral part of this endeavor and has produced many important discoveries in the areas of artificial organs, artificial implants, and diagnostic equipment.

At the undergraduate level, a four-year engineering curriculum leading to the B.S. degree in Biomedical Engineering is offered. This program prepares students for a wide variety of careers in Biomedical Engineering in industry, hospitals, and research laboratories or for further education in graduate school.

Also available is a four-year engineering curriculum which, together with required premedical courses, leads to the B.S. degree in Biomedical Engineering: Premedical. It is one of many majors that can serve as preparation for further training in medical, veterinary, or allied health professions. It is also suitable for students interested in pursuing graduate work in Biomedical Engineering and other biomedical areas such as physiology, neurosciences, and bioinformatics. The curriculum has less engineering content but more biological sciences than the Biomedical Engineering major.

Areas of graduate study and research include biomechanics, tissue engineering, biomedical computation, biophotonics, and biomedical nanoscale systems.

Undergraduate Major in Biomedical Engineering

The program objective is to prepare students for careers in the biomedical industry or for further education in graduate school. Biomedical Engineering students learn engineering and principles of biology, physiology, chemistry, and physics. They may go on to design devices to diagnose and treat disease, engineer tissues to repair wounds, develop cutting-edge genetic treatments, or create computer programs to understand how the human body works.

The curriculum emphasizes education in the fundamentals of engineering sciences that form the common basis of all engineering subspecialties. Education with this focus is intended to provide students with a solid engineering foundation for a career in which engineering practice may change rapidly. In addition, elements of bioengineering design are incorporated at every level in the curriculum. This is accomplished by integration of laboratory experimentation, computer applications, and exposure to real bioengineering problems throughout the program. Students also work as teams in senior design project courses to solve multidisciplinary problems suggested by industrial and clinical experience.

NOTE: Students may complete only one of the following programs: the major in Biomedical Engineering, the major in Biomedical Engineering: Premedical, or the minor in Biomedical Engineering.

ADMISSIONS

High School Students: See page 165.

Transfer Students. Preference will be given to junior-level applicants with the highest grades overall, and who have satisfactorily completed the following required courses: one year of calculus, one year of engineering physics (with laboratory), one year of chemistry, and one additional approved course for the major.

Students are encouraged to complete as many of the lower-division degree requirements as possible prior to transfer. Students who enroll at UCI in need of completing lower-division course work may find that it will take longer than two years to complete their degrees. For further information, contact The Henry Samueli School of Engineering at (949) 824-4334.

REQUIREMENTS FOR THE BACHELOR'S DEGREE IN BIOMEDICAL ENGINEERING

University Requirements: See pages 54-59.

School Requirements: See page 165.

Major Requirements

Mathematics and Basic Science Courses: Students must complete a minimum of 48 units of mathematics and basic sciences including:

Core Courses: Mathematics 2A-B, 2D, 2J, 3D, 2E, and Biological Sciences 7; Chemistry 1A-B-C and 1LB-LC; Physics 7A-B-D-E and 7LA-LB-LD; Biological Sciences 194S.

Elective Courses: Students select, with the approval of a faculty advisor, at least one additional basic science course needed to satisfy school and major requirements.

Engineering Topics Courses: Students must complete a minimum of 28 units of engineering design including:

Core Courses: ECE12, ECE20, CBEMS40A, BME1, BME50A-B, BME110A-B, BME111, BME120, BME121, BME130, BME140, BME150, BME160, BME170, BME180, BME181, BME199.

Engineering Electives: Students select, with the approval of a faculty advisor a minimum of 8 units of engineering topics needed to satisfy school and major requirements.

(The nominal Biomedical Engineering program will require 196 units of courses to satisfy all university and major requirements. Because each student comes to UCI with a different level of preparation, the actual number of units will vary).

MINOR IN BIOMEDICAL ENGINEERING

The minor in Biomedical Engineering requires a total of nine courses--two advanced mathematics courses, five core Biomedical Engineering courses, and two Biomedical Engineering electives. Some of these courses may include prerequisites that may or may not be part of a student's course requirements for their major. Private biomedical industry has indicated a keen interest in engineers that have a more traditional engineering degree (i.e., electrical engineering), but also possess some in-depth knowledge of biomedical systems. Hence, the minor in Biomedical Engineering is designed to provide a student with the introductory skills necessary to perform as an engineer in the biomedical arena.

Admissions. Students interested in the minor in Biomedical Engineering must apply through The Henry Samueli School of Engineering Student Affairs Office and must have a UCI cumulative GPA of 2.5 or higher.

NOTE: Students may not receive both a minor in Biomedical Engineering and a specialization in Biochemical Engineering within the Chemical Engineering major.

Requirements for the Minor in Biomedical Engineering

Mathematics Courses: Mathematics 2J, 3D.

Engineering Topics Courses: BME1, BME50A-B, BME120, BME121.

Technical Electives: Students select, with the approval of a faculty advisor, two technical elective courses: BME110A, BME110B, BME130, BME135 (same as Biological Sciences 130), BME136, BME136L, BME140, BME160, BME199, CBEMS124, CBEMS126, CBEMS154, ECE119, ECE178.

PLANNING A PROGRAM OF STUDY

The sample program of study chart shown is typical for the major in Biomedical Engineering. Students should keep in mind that this program is based upon a sequence of prerequisites, beginning with adequate preparation in high school mathematics, physics, and chemistry. Students who are not adequately prepared, or who wish to make changes in the sequence for other reasons, must have their program approved by their faculty advisor. Biomedical Engineering majors must consult at least once every year with the academic counselors in the Student Affairs Office and with their faculty advisors.

Sample Program of Study -- Biomedical Engineering

Undergraduate Major in Biomedical Engineering: Premedical

The major program objective is to prepare students for medical school. The curriculum is designed to meet the requirements for admission to medical schools, but is also suitable for those planning to enter graduate school in biomedical engineering, physiology, biology, neurosciences, or related fields. It has less engineering content and more biological sciences than the accompanying Biomedical Engineering major. It is one of many majors that can serve as preparation for further training in medical, veterinary, or allied health professions.

The Biomedical Engineering: Premedical curriculum provides future physicians with a quantitative background in biomechanics, bioelectronics, and biotransport. Such a background is increasingly important because of the heavy utilization of biomedical technology in modern medical practice. The curriculum includes courses in the sciences that satisfy the requirements of most medical schools. The education experience is enriched through a design course where students work as teams to solve Biomedical Engineering problems inspired by the clinical arena at the UCI Medical Center.

ADMISSIONS

High School Students: See page 165.

Transfer Students. Preference will be given to junior-level applicants with the highest grades overall, and who have satisfactorily completed the following required courses: one year of calculus, one year of engineering physics (with laboratory), one year of chemistry, and one additional approved course for the major.

Students are encouraged to complete as many of the lower-division degree requirements as possible prior to transfer. Students who enroll at UCI in need of completing lower-division course work may find that it will take longer than two years to complete their degrees. For further information, contact The Henry Samueli School of Engineering at (949) 824-4334.

REQUIREMENTS FOR THE BACHELOR'S DEGREE IN BIOMEDICAL ENGINEERING: PREMEDICAL

University Requirements: See pages 54-59.

School Requirements: See page 165.

Major Requirements

Mathematics and Basic Science Courses: Students must complete a minimum of 48 units of mathematics and basic sciences including: Mathematics 2A-B, 2D, 2J, and 3D; Chemistry 1A-B-C, 1LB-LC 51A-B-C, and 51LA-LB; Physics 7A-B-D-E and 7LA-LB-LD. Students select, with the approval of a faculty advisor, any additional basic science course needed to satisfy school and major requirements.

Engineering Topics Courses: Students must complete the following engineering topics including: Biological Sciences 97, 98, 99, 107 or 108, 100L, 111L, 194S, BME1, BME50A-B, BME110A-B, BME111,BME120, BME121,BME130, BME140, BME150, BME160 BME170, BME180, BME199. Students select, with the approval of a faculty advisor, any additional engineering topic course needed to satisfy school and major requirements.

(The nominal Biomedical Engineering: Premedical program will require 196 units of courses to satisfy all university and major requirements. Because each student comes to UCI with a different level of preparation, the actual number of units will vary).

PLANNING A PROGRAM OF STUDY

The sample program of study chart shown is typical for the major in Biomedical Engineering: Premedical. Students should keep in mind that this program is based upon a sequence of prerequisites, beginning with adequate preparation in high school mathematics, physics, and chemistry. Students who are not adequately prepared, or who wish to make changes in the sequence for other reasons, must have their program approved by their faculty advisor. Biomedical Engineering: Premedical majors must consult at least once every year with the academic counselors in the Student Affairs Office and with their faculty advisors.

Sample Program of Study --
Biomedical Engineering: Premedical

Graduate Study in Biomedical Engineering

The Biomedical Engineering faculty have special interest and expertise in three thrust areas: Biophotonics, Biomedical Nanoscale Systems, and Biomedical Computational Technologies. Biophotonics faculty are interested in photomedicine, laser microscopy, optical coherence tomography, medical imaging, and phototherapy. Biomedical Nanoscale Systems faculty are interested in molecular engineering, polymer chemistry, molecular motors, design and fabrication of microelectromechanical systems (MEMS), integrated microsystems to study intercellular signaling, and single molecule studies of protein dynamics. Biomedical Computation faculty are interested in computational biology, biomedical signal and image processing, bioinformatics, computational methods in protein engineering, and data mining.

Programs of study leading to the M.S. and Ph.D. degrees in Biomedical Engineering are offered.

Required Background

Because of its interdisciplinary nature, biomedical engineering attracts students with a variety of backgrounds. Thus, the requirements for admission are tailored to students who have a bachelor's degree in an engineering, physical science, or biological science discipline, with a grade point average of 3.0 or higher in their upper-division course work. The minimum course work requirements for admission are six quarters of calculus through linear algebra and ordinary differential equations, three quarters of calculus-based physics, three quarters of chemistry, and two quarters of biology. Students without a physics, chemistry, or engineering undergraduate degree may be required to take additional relevant undergraduate engineering courses during their first year in the program; any such requirements will be specifically determined by the BME Graduate Committee on a case-by-case basis and will be made known to the applicant at the time of acceptance to the program.

The recommended minimum combined verbal and quantitative portion of the GRE is 1200, or a minimum combined MCAT score in Verbal Reasoning, Physical Sciences, and Biological Sciences problems of 30. A minimum score of 600 on the Test of English as a Foreign Language (TOEFL) is recommended of all international students whose native language is not English. In addition, all applicants must submit three letters of recommendation.

Exceptionally promising UCI undergraduates may apply for admission through The Henry Samueli School of Engineering's accelerated M.S. and M.S./Ph.D. program, however, these students must satisfy the course work and letters of recommendation requirements described above.

Core Requirement

All students are required to take a set of core courses which total 22 units: BME 210, BME220, BME221, BME230A, BME230B, and BME240.

Elective Requirement

The remaining 14 units required to fulfill the course requirements for the M.S. and Ph.D. degree are comprised of elective courses offered within The Henry Samueli School of Engineering, the Schools of Biological Sciences and Physical Sciences, and the College of Medicine. A minimum of eight of the elective units must be taken from The Henry Samueli School of Engineering. The group of elective courses must be approved by the BME Graduate Committee, for M.S. students, or, for Ph.D. students, the student's graduate advisory committee, and are chosen to meet the specific needs of each student. The electives must provide breadth in biomedical engineering, but also provide specific skills necessary to the specific research the student may undertake as part of the degree requirements.

Areas of Emphasis

Although a student is not required to formally choose a specific research focus area, three research thrust areas have been identified for the program: Biophotonics, Biomedical Nanoscale Systems, and Biomedical Computational Technologies. The three areas capitalize on existing strengths within The Henry Samueli School of Engineering and UCI as a whole, interact in a synergistic fashion, and will train biomedical engineers who are in demand in both private industry and academia.

Biophotonics. This research area includes the use of light to probe individual cells and tissues and whole organs for diagnostic and therapeutic purposes. The research areas include both fundamental investigation on the basic mechanisms of light interaction with biological systems and the clinical application of light to treat and diagnose disease. Current and future foci of the faculty are: (1) microscope-based optical techniques to manipulate and study cells and organelles; (2) development of optically based technologies for the non-invasive diagnosis of cells and tissues using techniques that include fiber-optic-based sensors, delivery systems, and imaging systems; and (3) development of optically based devices for minimally invasive surgery.

Nanoscale Systems. This class of research areas encompasses the understanding, use, or design of systems that are at the micron or submicron level. Current strengths within The Henry Samueli School of Engineering and the UCI faculty as a whole include biomaterials, micro-electromechanical systems (MEMS), and the design of new biomedical molecules. The focus of biomedical engineering research in this area is the integration of nanoscale systems with the needs of clinical medicine. Projected areas of growth include: (1) micro-electromechanical systems (MEMS) for biomedical devices and biofluid assay; (2) programmable DNA/ molecular microchip for sequencing and diagnostics; and (3) biomaterials and self-assembled nanostructures for biosensors and drug delivery.

Biomedical Computational Technologies. Biomedical computational technologies include both advanced computational techniques, as well as advanced biomedical database systems and knowledge-base systems. Computational technologies that will be developed in this research area include: (1) methods for biomedical analysis and diagnosis such as physical modeling of light-tissue interactions, atomic-level interactions, image processing, pattern recognition, and machine-learning algorithms; (2) language instruction and platform standardization; and (3) machine-patient interfaces. Areas of research related to biomedical database systems include the development of new technologies which can capture the rich semantics of biomedical information for intelligent reasoning.

MASTER OF SCIENCE DEGREE

Two options are available for the M.S. degree: a thesis option and a comprehensive examination option. Both options require the student to specify an area of specialty, and to complete a minimum of 36 units, at least 28 of which must be at the 200 level including the 22 units that comprise the core courses as described above. The degree will be granted upon the recommendation of the Director and The Henry Samueli School of Engineering Associate Dean of Graduate Studies.

Plan I: Thesis Option

A thesis option is available to students who prefer to conduct a focused research project. Students selecting this option must select a thesis advisor and complete an original research investigation including a written thesis, and obtain approval of the thesis by a thesis committee. A maximum of eight M.S. research units (i.e., ECE296) may be applied toward the 36-unit requirement.

Plan II: Comprehensive Examination Option

Alternatively, students may select a comprehensive examination option in which they must successfully complete 36 units of study and pass a comprehensive examination. The preliminary examination in the Ph.D. program, described below, will serve as the comprehensive examination. However, the passing grade to qualify at the Master's competency level will be lower than the grade required for a student to advance in the Ph.D. program.

DOCTOR OF PHILOSOPHY DEGREE

The Ph.D. degree requires the achievement of an original and significant body of research that advances the discipline. Students with a B.S. degree may enter the Ph.D. program directly, provided they meet the background requirements described above. The Graduate Committee will handle applicants on a case-by-case basis, and any specific additional courses required by the student will be made explicit at the time of admission.

Each student is matched with a faculty advisor, and an individual program of study is designed by the student and a faculty advisory committee. There are no additional course requirements beyond that of the M.S. degree. Four milestones are required: (1) successful completion of 36 units of course work beyond the bachelor's degree, at least 28 of which must be at the 200 level including the 22 units of core course requirements; (2) successful completion of a preliminary examination at the Ph.D. competency level; (3) formal advancement to candidacy by successfully passing a qualifying examination; and (4) completion of a significant body of original research and the submission of an acceptable written dissertation and its successful oral defense.

The preliminary examination will normally be taken at the end of the first year (July), but will also be offered in December. A student must take it within two years of matriculating in the program, and must either have passed all of the core courses or have an M.S. degree prior to taking the examination. The Graduate Committee prepares the examination and sets two minimum competency levels, one for awarding the Master's degree and the second for continuing on in the Ph.D. program. Students who fail to pass at the Ph.D. level may retake the examination once within six months of the initial attempt. Students who fail the second attempt will not be allowed to continue in the program. Students who pass either attempt at the Master's competency level will be awarded an M.S. degree. After passing the preliminary examination at the Ph.D. competency level, students are matched with a BME faculty advisor and design an individual program of study with their advisor.

Advancement to candidacy must be completed between the ninth and twelfth quarters of enrollment, usually during a student's third year. (Special exceptions can be made, but a formal request with justification must be supplied in writing to the Director.) The qualifying examination follows campus and The Henry Samueli School of Engineering guidelines and consists of an oral and written presentation of original work completed thus far, and a coherent plan for completing a body of original research. The qualifying examination is presented to the student's graduate advisory committee, which is selected by the student and faculty advisor and must have a minimum of five faculty (including the faculty advisor). Of these five faculty, a minimum of three must be affiliated BME faculty. In addition, a minimum of two faculty must have part of their primary appointment in The Henry Samueli School of Engineering.

The Ph.D. is awarded upon submission of an acceptable written dissertation and its successful oral defense. The degree is granted upon the recommendation of the graduate advisory committee and the Dean of Graduate Studies. Completion of the Ph.D is expected in the fifth year following completion of the B.S. degree, although a maximum of seven years (28 academic quarters) is allowed.

Courses in Biomedical Engineering

LOWER-DIVISION

BME1 Introduction to Biomedical Engineering (2) W. Introduction to the central topics of biomedical engineering. Offers a perspective on bioengineering as a discipline in a seminar format. Principles of problem definition, team design, engineering inventiveness, information access, communication, ethics, and social responsibility are emphasized. (Design units: 1)

BME50A-B Cell and Molecular Engineering (4-4) W, S. Physiological function from a cellular, molecular, and biophysical perspective. Applications to bioengineering design. (Design units: 2 each)

UPPER-DIVISION

BME110A Biomechanics I (4) F. Introduction to continuum mechanics of both living and nonliving bodies. The laws of motion and free-body diagrams. Stresses. Deformation. Compatibility conditions. Constitutive equations. Properties of common fluids and solids. Derivation of field equations and boundary conditions. Applications to bioengineering design. Prerequisites: Physics 7D, 7LD, 7E. (Design units: 1)

BME110B Biomechanics II (4) W. Introduction to the mechanics of physiological systems. Application of mechanics to understand the structure/function relationship at gross and microscopic levels. Bioelastic solids. Rigid body biomechanics. Biofluids. Bioengineering and medical design. Prerequisite: BME110A. (Design units: 1)

BME111 Design of Biomaterials (4) S. Natural and synthetic polymeric materials. Materials characterization and design. Wound repair, blood clotting, foreign body response, transplantation biology, biocompatibility of materials, tissue engineering. Artificial organs and medical devices. Government regulations. Patenting. Ethical issues. Prerequisites: BME110A-B. (Design units: 3)

BME120 Quantitative Physiology: Sensory Motor Systems (4) F. A quantitative and systems approach to understanding physiological systems. Systems covered include the nervous and musculoskeletal systems. Prerequisite: Mathematics 3D or equivalent, or consent of instructor. Concurrent with BME220. Formerly Engineering E110B. (Design units: 2)

BME121 Quantitative Physiology: Organ Transport Systems (4) W. A quantitative and systems approach to understanding physiological systems. Systems covered include the cardiopulmonary, circulatory, and renal systems. Prerequisite: Mathematics 3D or equivalent, or consent of instructor. Same as CBEMS104. Concurrent with BME221, CBEMS204. Formerly Engineering E110A. (Design units: 1).

BME130 Biomedical Signals and Systems (4) F. Biomedical signal analysis in a vector space of signals: cluster analysis; orthogonal expansions; Fourier Series expansions; linear least squares estimation. Dynamical system models: analysis of forward (system responses) and inverse (system identification and inversion) problems. Class projects on applications. Prerequisites: Mathematics 2J; Mathematics 7 recommended. (Design units: 1)

BME135 Photomedicine (4) F. Studies the use of optical and engineering-based systems (laser-based) for diagnosis, treating diseases, manipulation of cells and cell function. Physical, optical, and electro-optical principles are explored regarding molecular, cellular, organ, and organism applications. Prerequisites: Physics 3A-B-C or 7A-B-D, or ECE10 or consent of instructor. Same as Biological Sciences 130. Formerly ECE175. (Design units: 0)

BME136 Engineering Optics for Medical Applications (3) W. Fundamentals of optical systems design, integration, and analysis used in biomedical optics. Design components: light sources, lenses, mirrors, dispersion elements, optical fibers, detectors. Systems integration: microscopy, radiometry, inteferometry. Optical system analysis: resolution, modulation transfer function, deconvolution, interference, tissue optics, noise. Corequisite: BME136L. Prerequisites: BME135, ECE170, or consent of instructor. Formerly ECE176. (Design units: 1).

BME136L Engineering Optics for Medical Applications Laboratory (1) W. Optical system design and data analysis: microscopy, imaging, spectral analysis, interferometry, tomography, radiometry. Corequisite: BME136. Prerequisites: BME135 and ECE170 or consent of instructor. Formerly ECE176L. (Design units: 0)

BME 140 Design of Biomedical Electronics (4) W. Analog and digital circuits in bioinstrumentation. Biomedical signals in continuous and discrete systems. Sampling and digital signal processing. MRI; CT; ultrasound; bioelectromagnetics; electrokinetics. Applications to bioengineering design. Prerequisite: BME130. (Design units: 3)

BME 150 Biological Mass Transfer (4) S. Mass transfer in gas, liquid and solid with application to biological systems. Free and facilitated diffusion, active transport, convective mass transfer, diffusion-reaction phenomena, biological mass transfer coefficients, steady and unsteady transport, and flux-force relationships. Applications to bioengineering design. Prerequisites: BME110A-B. (Design units: 1)

BME160 Tissue Engineering (4) S. Quantitative analysis of cell and tissue functions. Emerging developments in stem cell technology, biodegradable scaffolds, growth factors, and others important in developing clinical products. Applications to bioengineering design. Prerequisites: BME50A-B, BME121. (Design units: 2)

BME170 Biomedical Engineering Laboratory (4) F. Laboratory experiments involving living systems with the emphasis on biophotonics, nanoscale systems, and physiological systems. Five laboratories are planned including image processing, Optical Computed Tomography, dynamic cooling, respiratory gas exchange, and electroosmotic transport phenomena. Study of possible errors. Prerequisites: BME111, BME120, BME121, BME130, BME140. (Design units: 1)

BME180 Biomedical Engineering Clinical Design (4) W. Design strategy and concepts commonly encountered in biomedical engineering such as reliability, safety, ethics, economic analysis, and marketing. Bioethical issues are discussed. A cardinal feature of this course is a clinical experience at the UCI Medical Center and Beckman Laser Institute. (Design units: 4)

BME181 Biomedical Engineering Industrial Design (4) S. Design strategy and concepts commonly encountered in biomedical engineering. A cardinal feature of the course is an industrial design project developed in partnership with the Center for Biomedical Engineering's industrial sponsors and Corporate Advisory Board. Prerequisites: BME111, BME120, BME121, BME140, BME150. (Design units: 4)

BME195 Special Topics in Biomedical Engineering (1 to 4) F, W, S. Prerequisites vary. May be repeated for credit. (Design units: varies)

BME196 Biomedical Engineering Thesis (4) F, W, S. Preparation of final presentation and paper describing individual research in biomedical engineering in one or more quarters of individual study (i.e., BME199). Prerequisites: satisfactory completion of lower-division writing requirement, completion of at least four units of BME199, and consent of BME199 instructor. (Design units: varies).

BMEH196 Biomedical Engineering Honors Thesis (4) F, W, S. Preparation of final presentation and paper describing individual research in biomedical engineering. Prerequisites: BMEH199 and consent of instructor. Open only to members of the Campuswide Honors Program who are Biomedical Engineering or Biomedical Engineering: Premedical majors. (Design units: varies)

BME199 Individual Study (1 to 4) F, W, S. Independent research conducted in the laboratory of a Biomedical Engineering core faculty member. A formal written report of the research conducted is required at the conclusion of the quarter. Prerequisites: Biological Sciences 194S and consent of instructor. May be repeated for credit. (Design units: varies)

BMEH199 Individual Study for Honors Students (1 to 4) F, W, S. Independent research conducted in the laboratory of a Biomedical Engineering faculty member for participants in the Campuswide Honors Program. A formal written report of the research conducted is required at the conclusion of quarter. Prerequisites: Biological Sciences 194S and consent of instructor. Open only to members of the Campuswide Honors Program who are Biomedical Engineering or Biomedical Engineering: Premedical majors. May be repeated for credit. (Design units: varies)

GRADUATE

BME210 Cell and Tissue Engineering (4) F. A biochemical, biophysical, and molecular view of cell biology. Topics include the biochemistry and biophysical properties of cells, the extracellular matrix, biological signal transduction, and principles of engineering new tissues. Prerequisite: consent of instructor. Formerly Engineering 205.

BME220 Quantitative Physiology: Sensory Motor Systems (4) F. A quantitative and systems approach to understanding physiological systems. Systems covered include the nervous and musculoskeletal systems. Prerequisite: consent of instructor. Concurrent with BME120. Formerly Engineering 210B.

BME221 Quantitative Physiology: Organ Transport Systems (4) W. A quantitative and systems approach to understanding physiological systems. Systems covered include the cardiopulmonary, circulatory, and renal systems. Prerequisite: consent of instructor. Same as CBEMS204. Concurrent with BME121, CBEMS104. Formerly Engineering 210A.

BME230A Applied Engineering Mathematics I (4) F. Analytical techniques applied to engineering problems in transport phenomena, process dynamics and control, and thermodynamics. Prerequisites: CBEMS110, CBEMS120A, and CBEMS120B; or consent of instructor. Same as CBEMS230.

BME230B Applied Engineering Mathematics II (4) W. Advanced engineering mathematics for biomedical engineering. Focuses on biomedical system identification. Includes fundamental techniques of model building and testing such as formulation, solution of governing equations (emphasis on basic numerical techniques), sensitivity theory, identifiability theory, and uncertainty analysis. Formerly Engineering 220B.

BME240 Introduction to Clinical Medicine for Biomedical Engineering (2) S. An introduction to clinical medicine for graduate students in biomedical engineering. Divided between lectures focused on applications of advanced technology to clinical problems and a series of four rotations through the operating room, ICU, interventional radiology/imaging, and endoscopy. Formerly Engineering 240.

BME261A Biomedical Microdevices I (3) S. In-depth review of microfabricated devices designed for biological and medical applications. Studies of the design, implementation, manufacturing, and marketing of commercial and research bio-MEMS devices. Prerequisite: ECE217 or consent of instructor. Formerly Engineering 261A.

BME295 Special Topics in Biomedical Engineering (1 to 4) F, W, S. Prerequisites vary. May be repeated for credit as topics vary.

BME296 Master of Science Thesis Research (1 to 12). Individual research or investigation conducted in the pursuit of preparing and completing the thesis required for the M.S. in Engineering. Prerequisite: consent of instructor. May be repeated for credit.

BME297 Doctor of Philosophy Dissertation Research (4 to 12). Individual research or investigation conducted in the pursuit of preparing and completing the dissertation required for the Ph.D. in Engineering. Prerequisite: consent of instructor. May be repeated for credit.

BME298 Seminars in Biomedical Engineering (1) F, W, S. Presentation of advanced topics and reports of current research efforts in biomedical engineering. Designed for graduate students in the biomedical engineering program. Prerequisite: consent of instructor. May be repeated for credit. Formerly Engineering 298.

BME299 Individual Research (1 to 12). Individual research or investigation under the direction of an individual faculty member. Prerequisite: consent of instructor. May be repeated for credit.