FROM THE CHANCELLOR

CICERONE Welcome to the Irvine campus and to a new world of intellectual opportunity for you as a student. UCI's reputation for innovation and high academic standards is attracting more of the nation's brightest students and faculty. UCI students compete successfully for the most coveted scholarships and fellowships. Their competitive edge comes from being at a research university where involvement in the intense creativity of the research process often begins during the undergraduate years.

UCI is regarded as one of the finest public universities in the country. And many of our programs have achieved standing with those of the best private universities. Our strong faculty are the key. Two of UCI's founding faculty have received Nobel Prizes. Many others have attained worldwide recognition for their research, while gaining equal respect on campus for their ability to engage students in the excitement of learning. Faculty also are responsible for UCI's growing strengths in virtually every discipline from the arts, humanities, and social sciences, to technology and management.

Increasingly, society and the workplace demand knowledge that crosses traditional boundaries. So we have developed programs that combine studies such as art and technology, medicine and engineering, ecology and the social sciences, business and computer sciences, all designed to prepare students for roles as citizens and scholars in the new century.

UCI's partnerships with the fast-growing Orange County community also create incomparable opportunities for our students. They include work experience in a dynamic international marketplace, learning as they serve the community through the campus' outreach and public service groups, or simply benefiting from the advice of UCI alumni and leaders from every area of society.

Whether you are a graduate or undergraduate student, UCI offers a place to pursue whatever course you have in mind for your future, or to change that course should you decide to explore other educational goals. I look forward to seeing you on campus, and to sharing these next few years in your lifetime of learning.

Sincerely,

Ralph J. Cicerone
Chancellor

UCI ACADEMIC SENATE DISTINGUISHED FACULTY

NANCY L. ALLBRITTON

Distinguished Mid-Career Award for Research, 2003-04

Associate Professor of Physiology and Biophysics, Biological Sciences, and Biomedical Engineering

ALLBRITTON Nancy Allbritton grew up in rural Louisiana and graduated from Louisiana State University with a B.S. in Physics in 1979. After three years at the Johns Hopkins University School of Medicine, her intense interest in scientific research and strong background in the physical sciences led her to take a leave of absence from medical school to pursue a Ph.D. in Medical Physics in the combined Medical Physics/Medical Engineering Program between the Massachusetts Institute of Technology and Harvard University. After passing her physics qualifying exams at MIT, she returned to medical school at Johns Hopkins, completing her M.D. degree in 1985. She then completed her graduate training with Dr. Herman Eisen, a pioneer in the field of immunology, receiving a Ph.D. in Medical Engineering and Medical Physics from MIT in 1987. After an NIH postdoctoral fellowship with Dr. Lubert Stryer at Stanford University, she joined the faculty in the Department of Physiology and Biophysics at UC Irvine in 1994.

Her formal training provided the foundation on which she has built a unique and successful research program at UCI, her research being distinguished by the application of principles from the physical sciences to answer questions in the biological sciences. Shortly after her arrival at UCI, she received two highly prestigious honors in 1995, a Beckman Young Investigator Award and a Searle Scholar Award, for her innovative research plans. During her time at UCI she has pursued these ideas and built a vigorous laboratory based on the development of new analytical technologies with applications to the biomedical sciences. Dr. Allbritton's research program has brought more than $8.5 million to UCI in grant funding. Reflecting the highly interdisciplinary character of her research, she has published numerous articles in top-tier journals in both biology and chemistry and has been an invited speaker at numerous universities and research conferences in both fields.

There is tremendous interest in understanding how cells receive and process signals in order to carry out a given cellular response, a field known as cellular signal transduction. The research objective of the Allbritton Lab is to quantitatively measure cellular signaling networks in order to understand the relationships of these intracellular pathways in health and disease. In order to elucidate these complex interrelationships, measurements on individual cells must be undertaken. Dr. Allbritton has tackled this formidable task by bringing to bear her diverse background in biomedicine, physics, chemistry, and engineering to develop new analytical techniques to identify molecular circuits within a single cell. This research has involved a number of biological systems including the roles of inositol (1,4,5)-trisphosphate and calcium in cell signaling, quantifying the activity of enzymes that make up cellular signaling networks, and development of nanoscale technologies for biomedical applications including cancer screening, chemical analysis of single cells, and engineering with modular biopolymers. Dr. Allbritton holds three U.S. patents, three pending patent applications, and more than 10 disclosures of intellectual property to The UC Regents. She is also the intellectual founder of a biotechnology company that has been established to commercialize the novel technology based on her research and patents.

ZANG-HEE CHO

Distinguished Faculty Award for Research, 2003-04

Professor of Radiological Sciences, Psychiatry and Human Behavior, and Biomedical Engineering

CHO Born in Seoul, Korea, in 1936, Zang-Hee Cho attended Seoul National University and graduated with a B.Sc. and M.Sc. in 1960 and 1962, respectively. He continued his study at Uppsala University (Sweden), obtaining his Ph.D. in 1966. Before joining UCI in 1985, he had faculty positions at the University of Stockholm, UCLA, and Columbia University.

Important milestones in modern neuroscience must include the development of techniques and devices with which one can observe changes in brain chemistry and physiology, such as blood flow and chemical changes. Some of the most recent developments are Positron Emission Tomography (PET) and functional Magnetic Resonance Imaging (fMRI). These developments make it possible to observe cortical changes in the brain due to internal as well as external stimuli such as light flashes and acupuncture.

Professor Cho has been in this area since the inception of computerized tomography (CT) in 1972. He was one who pioneered mathematical algorithms related to CT scanners and developed one of the first 3-D image reconstruction algorithms. Professor Cho's subsequent work based on 3-D image reconstruction was the first "Ring PET" and its nuclear detector "Bismuth Germanate Oxide (BGO)," both of which revolutionized modern brain imaging. Today, invariably all PET scanners, both research prototypes and commercial devices, are "Ring" types with "BGO" nuclear scintillation detectors. Today's high-resolution PET scanners are a reality, thanks to the introduction of these two key elements.

Since the late 1970s, Professor Cho has been engaged in MRI research and has developed numerous high-speed imaging techniques and methods essential for today's fMRI such as the "Spiral Scan Echo Planar" technique and MRI venography using the magnetic susceptibility effect produced by deoxyhemoglobin.

More recently, as an application of functional brain imaging, Professor Cho pioneered Acupuncture-Brain Imaging, a new approach to Oriental medicine utilizing the latest imaging techniques such as PET and fMRI. This study, for the first time, demonstrated that there is a correlation between acupuncture stimulation and activation of the corresponding brain cortex and opened a new research avenue for complementary and alternative medicine.

Professor Cho's lifelong contributions to the areas of computerized tomography and related imaging physics has changed the course of modern medical imaging and profoundly influenced modern neuroscience research. For these contributions, he was made a Distinguished Medical Imaging Scientist at the Computerized Tomography Symposium held at Asilomar, California, in 1982 and was recognized not only as the inventor of PET and a pioneer of computerized tomography but also as one of the most cited scientists in the field of CT and medical imaging at the time. He holds numerous other honors and awards including membership in the National Academy of Sciences-Institute of Medicine, the National Academy of Sciences-Republic of Korea, and The Third World Academy of Sciences. Professor Cho is the Editor in Chief of the International Journal of Imaging Systems and Technology and also serves as an editorial board member of various scientific journals related to imaging. He is currently a member of the National Advisory Council for the NIH National Center for Complementary and Alternative Medicine in Washington, D.C.

ROY M. FUJITANI

Distinguished Faculty Award for Teaching, 2003-04

Chief of the Division of Vascular Surgery and Associate Professor of Surgery (Vascular)

FUJITANI The small, unpretentious plantation town of Honoka'a on the Big Island of Hawaii is where I grew up during my formative years, laying the foundation of my future as an academic vascular surgeon. My father, a hard-working, blue-collar rancher, taught me early in life the virtues of craftsmanship, diligence, and the vigilance to detail. My mother taught me the value of a good education, humility, and having compassion for others. Coupling my intense interest in the sciences and people, even very early in life, I decided to pursue a medical career.

I left my mid-Pacific home to attend Creighton University in Omaha, Nebraska, where I assimilated to my first bitterly cold winter--not necessarily a small feat for a thin-skinned Hawaiian native. Earning a B.S. in Biological Sciences from the University of Southern California in 1979, I returned to the University of Hawaii John A. Burns School of Medicine, receiving my M.D. degree in 1983. The Harbor-UCLA Medical Center served as my designated second-home for the next six years as I completed a residency in General Surgery, including a year dedicated to a vascular surgical research fellowship. I became intensely intrigued with the logical complexities of the human vascular system and its various disease conditions. This led to my furthering my training in a vascular surgery fellowship at the University of Chicago Hospitals under the mentorship of Drs. Christopher Zarins and Bruce Gewertz.

Serving under the auspices of the U.S. Air Force Medical Corps at the Wilford Hall Medical Center (Lackland AFB, San Antonio, Texas) and Uniformed Services University of the Health Sciences brought forth an appointment as Chief Consultant to the Surgeon General in Vascular Surgery. This tertiary patient-care venue led to my being able to refine my clinical and academic interests in vascular surgery, including translational clinical research of the evolving imaging and endovascular technologies. Upon completion of my military obligation, I was recruited by Dr. Samuel E. Wilson to the UCI College of Medicine, Department of Surgery in 1996 to serve as Chief of the Division of Vascular Surgery.

Although the coupling of the daily clinical activities in providing compassionate, state-of-the-art patient care with demanding research and administrative duties has become much more challenging in the current academic milieu, I cannot imagine a better job! Along with the privilege of improving and saving lives, comes the responsibility of assuring the formal surgical education and training of our medical students and house officers--this remains a major commitment of mine. From a research standpoint, my current interests include the correlation of atherosclerotic plaque histology/morphology with available imaging techniques to predict (and prevent) acute clinical events.

My family and friends have been, and will always remain, the most important component of my life. With a deep sense of humility, I am extremely grateful for being designated to receive the 2003-04 UCI Academic Senate Distinguished Faculty Award for Teaching. Realizing the extremely dedicated and talented pool of faculty that our esteemed University engenders, this special recognition is especially meaningful.

R. DUNCAN LUCE

Daniel G. Aldrich Jr. Distinguished University Service Award, 2003-04

Distinguished Professor Emeritus of Cognitive Sciences and Economics

LUCE Early Years. Airplanes and painting captured my attention until college. My parents weighed in strongly against a career in art, for which we are all probably better off, and astigmatism ruled out military flying. (In 1966 I learned to fly and for a few years owned a light plane.) At 17 I entered MIT in aeronautical engineering (1942), enlisted in the Navy V12 program (1943), graduated (1945), went to midshipman school (Notre Dame) and Catapult and Arresting Gear School (Philadelphia), followed by the shake-down cruise of the aircraft carrier Kearsarge.

On discharge (1946) I returned to MIT in applied mathematics. Applications in the behavioral sciences soon attracted me. Various nontraditional topics were in the wind in Cambridge-- information theory, game theory, and cybernetics--and I learned a bit of each. After meeting Leon Festinger and Alex Bavelas, my interests turned to what is now called social networks, currently an active UCI area. The year 1950 saw my Ph.D. (topics in semigroups), marriage to Gay Gaer (which ended in divorce), and a major career choice: mathematics with a minor in behavioral science or mathematical behavioral science. Opting for the latter resulted in an uneasy nine years until I was firmly accepted by the behavioral science community.

Professional Positions. My first official position was in Bavelas' small groups laboratory where I was first exposed to the actual interplay of data and mathematical theory, received a fine informal education in the weekly seminars on information theory, and was informally tutored by a number of scientists who ultimately became well known: Noam Chomsky, William McGill, George Miller, and Walter Rosenblith. Paul Lazarsfeld, a prominent sociologist at Columbia, invited me to be managing director of a research project in mathematical social science (1953) and, ultimately, assistant professor of sociology and mathematical statistics. At his invitation I spent, as did he, the inaugural year at the Center for Advanced Study in the Behavioral Sciences (CASBS), Stanford. Next, statistician Frederick Mosteller arranged an appointment at Harvard's Social Relations (1957). Two years later, through efforts of Robert Bush and Eugene Galanter, I was appointed full professor of Psychology at the University of Pennsylvania and during the 1960s participated in the renaissance of that department. The 1950 bet had paid off.

Following a divorce, Cynthia Newby and I married (1967), and after a year in Rio de Janeiro I became a visiting professor in the social science faculty at the (Princeton) Institute for Advanced Study. Among the visitors was John Yellott (UCI) who, when bitter controversy over the nature of that faculty made the Institute unpleasant, urged my first UCI appointment (1972). That winter Aurora, my only child, was born. Three years later Cynthia and Aurora departed for Brazil, a divorce ensued, and somewhat frustrated by the then chaos of the School of Social Sciences, I left to become the IBM Alfred North Whitehead Professor of Psychology at Harvard. That chair "folded" after five years, and I was made Victor S. Thomas Professor, which became an emeritus title in 1988. I chaired Harvard's Psychology Department for three years. In 1987-88 I went to CASBS, for a third time, where two major events unfolded for me. My long-term companion Carolyn Scheer and I married. At the Center I worked with a group that included Louis Narens (UCI) who, with the then Dean of Social Sciences William Schonfeld, arranged a faculty appointment and the founding of the Irvine Research Unit for Mathematical Behavioral Sciences. During the decade I was director we became an Institute and raised monies for various activities: a training grant, eight international conferences and workshops (up to four weeks) held at UCI, and a number of interdisciplinary research projects. The Institute, while rivaled by other similar activities in specific disciplines, was unrivaled in the world for promoting interdisciplinary mathematical modeling in the social and behavioral sciences broadly. Since retiring from UCI, I have been on recall with my main focus on research and service.

Indices and Honors. Publications: Nine volumes authored or coauthored, 13 edited ones, and 205 scientific journal articles and book chapters (with nine more in various stages of completion). Honors: Tau Beta Pi and Sigma Xi (1945), the Society of Experimental Psychologists (1963), American Academy of Arts and Sciences (1966), Distinguished Scientific Contributions Award from the American Psychological Association (1970), National Academy of Sciences (1972), Phi Beta Kappa (1975), American Philosophical Society (1995), the UCI Medal (2001), and a Gold Medal Award for Life Achievement in the Science of Psychology from the American Psychological Foundation (2001).

Professional and Service Activities. These include numerous roles in the National Academy of Sciences (section and class chair), the National Research Council (chair of the Assembly of Behavioral and Social Sciences), and professional societies (presidents of the Society for Mathematical Psychology and the Psychometric Society, various boards of directors). And I served on a number of University, campus, and department committees. During 2002 I chaired the committee that led to the founding of the UCI Department of Statistics and selected its first chair, Hal Stern.

JUSTIN L. TOBIAS

Distinguished Assistant Professor Award for Teaching, 2003-04

Assistant Professor of Economics

TOBIAS I have always had strong interests in mathematics and statistics and, not surprisingly, decided to major in mathematics as an undergraduate. I completed the required course work for the mathematics major reasonably quickly, took several independent studies on more advanced mathematical topics, and sometime late in my sophomore year I rather casually decided to throw in a double major in economics.

As a result of that decision I was required to enroll in a course in econometrics. I became instantly addicted to the subject. Econometrics provided me with the opportunity to apply the statistical techniques that held my fascination to the study of important problems in the social sciences. For me, econometrics offered an irresistible marriage of what I enjoyed most about both fields.

I continued my education in economics and econometrics at the University of Chicago. There I was extremely fortunate to conduct my dissertation research under the supervision of two pioneers in the field, James Heckman and Arnold Zellner. I am particularly indebted to Professor Zellner for introducing me to the exciting world of Bayesian econometrics and for sharing with me his passion for the subject. I am now its lifelong student.

My current research involves the development and application of simulation-based Bayesian methods for inference. My work tends to be predominantly empirical in nature, and in one strain of my research I have described how Bayesian statistical methods can be used to provide a more general approach to the evaluation of social programs. In broad terms, the process of social program evaluation involves the use of statistical methods to estimate the economic return to a "treatment"--such as participating in a job training program or deciding to attend college. Unlike clinical trials, individuals in typical social science data sets are not randomly assigned to the "treated" and "untreated" states. For example, those who decide to attend college probably differ from those who do not in dimensions that are both observed and unobserved by the researcher. This reality creates significant problems for standard estimation methods, and our ongoing efforts to solve this problem have been chronicled in a rich and fascinating literature.

At UCI I have been extremely fortunate to teach a variety of courses in econometrics. These have ranged from large introductory undergraduate classes to small graduate courses in applied Bayesian methods. I thoroughly enjoy sharing my enthusiasm for the subject with my students and feel honored to play a role in their empirical and statistical development.

QUN-YONG ZHOU

Distinguished Assistant Professor Award for Research, 2003-04

Associate Professor of Pharmacology

ZHOU During my pharmacy school years, I was impressed by the beautiful dose-responsive curves of drugs. But receptors, the supposed action targets of these drugs, were more imaginary than tangible biochemical identities. After a pharmacy internship, I was very disappointed to learn that all a pharmacist did was to read the scribbles of a medical doctor and count the number of pills requested. So, upon graduation, I entered a biochemistry graduate program, first at Shanghai Institute of Biochemistry, then at Vollum Institute of Oregon Health Sciences University. As a Ph.D student in Professor Olivier Civelli's laboratory at Vollum Institute, I truly found my interest for receptors, particularly a family of receptor called G protein-coupled receptor (GPCR), which remains my current research focus. While it was known that GPCRs probably account for a good chunk of all drugs on the market, most of them remained elusive at that time. The main part of my thesis work was to clone dopamine D1 receptor without trying to purify the receptor protein. Dopamine D1 receptor is a crucial target for drugs that treat Parkinson's disease and schizophrenia. After a few frustrating months, I was finally able to design a successful approach based on polymerase chain reaction, a fairly new technique at that time. When our paper describing the molecular cloning of dopamine D1 receptor was accepted by Nature, I felt for first time how rewarding scientific research could be. I surely felt how tangible the receptor really was when holding the x-ray film that recorded the nucleotide sequence of dopamine D1 receptor.

After my graduation, I did a postdoctoral fellowship with a pioneer in transgenic mice. In Professor Richard Palmiter's laboratory at University of Washington, I applied the genetic approach to study the physiology and pharmacology of dopamine and dopamine receptors. I kept focusing on dopamine receptors when I started my own group, first at University of Toronto and then at UCI. A side project of the laboratory was to isolate the endogenous ligand for an orphan GPCR, a by-product when I tried to clone dopamine D1 receptor. This effort has eventually led us to the elucidation of a complete new family of signaling molecules, the prokineticins.

The last three or four years have been very exciting for our prokineticin research. We have first identified two prokineticin molecules and then two closely related receptors (belonging to GPCR) that mediate the biological functions of prokineticins. We have been able to shown that prokineticins are crucial regulators for gastrointestinal motility. More recently, we have elucidated a totally unexpected function for the prokineticin system. We have been able to demonstrate that prokineticin 2 functions as a timing messenger for the circadian clock that organizes our daily physiology and behavior rhythms. We have found that prokineticins and their receptors hold promise as possible therapeutics or drug targets for a number of important disorders, such as irritable bowel syndrome, jet-lag, shift work syndrome, and chronic insomnia.

An important and enjoyable aspect of my UCI experience has been as a mentor for a few talented graduate students. I was fortunate enough to be able to work with them side by side during their young and extremely creative years.


home Table of Contents