OFFICE OF RESEARCH
Susan V. Bryant, Vice Chancellor for Research
The mission of the Office of Research (OR) is to support, facilitate, and promote world-class research at the University of California, Irvine. As its primary activity, OR works with other campus units to foster an environment for research and artistic activity that facilitates the discovery and dissemination of knowledge in many forms to all levels of society.
OR provides central campus administrative support for UCI's research programs. It includes the Office of Research Administration (ORA), the Office of Technology Alliances (OTA), University Laboratory Animal Resources (ULAR), Research Development, Administrative Operations and Information Technology, and the Office of the Vice Chancellor. Each of these units contributes to the overall objective of facilitating campus research activities in a variety of ways.
The Office of Research Administration (ORA) consists of Sponsored Projects, Research Protections, Conflict of Interest, and export control. ORA is the office of record for extramural proposals and awards supporting research, education, and public service activities of UCI faculty, staff, and students. ORA staff members are expert resources for policy and program information and act as administrative contacts with external regulatory agencies, higher education organizations and professional societies, and other universities to discuss regulatory changes, institutional policy developments, and overall awareness of regulatory requirements and enhancements.
The Office of Technology Alliances (OTA) fosters research collaboration and transfers of technology between UCI and industry, striving for rapid commercialization of research results for the public benefit. It plays an important role in linking faculty and new technology with companies that can collaborate in both the further development of new inventions and the commercialization of research results.
University Laboratory Animal Resources (ULAR) manages the housing, feeding, and care of all research animals housed in UCI facilities. It fulfills four main functions: veterinary services, animal husbandry, transgenic mouse facility, and business and purchasing administration.
The Office of Research Development is complemented by research development professionals assigned to specific schools, departments, and research units, and contributes significantly to faculty success in securing research support from granting agencies.
Administrative Operations and Information Technology provides administrative and network and computing support to OR's core administrative units as well as over 30 Organized Research Units and Special Research Programs that report to OR.
The Office of the Vice Chancellor supports and coordinates the activities of the Vice Chancellor and the Associate Vice Chancellors, and represents OR in interfacing with campus management and the academic units.
Special Research Programs
Special Research Programs (SRPs) exist at UC Irvine to provide a structure for collaborative research activities that do not fit the definition and purpose of an Organized Research Unit, a Campus Center, or a School Center.
BECKMAN LASER INSTITUTE
The Beckman Laser Institute (BLI) was established in 1982 by Dr. Arnold O. Beckman and Dr. Michael W. Berns as an interdisciplinary center for the development and application of optical technologies in biology and medicine. Since the opening in 1986, Beckman Laser Institute has grown to include 18 faculty and their 130 affiliated students, postdoctoral fellows, technical staff, and administrative support. BLI is one of five national Beckman Institutes supported by the Arnold and Mabel Beckman Foundation. BLI is dedicated to cutting-edge interdisciplinary research and the interface of physical science, engineering, and biology. Because BLI also houses a medical clinic, it is unique in its capacity for conducting translational research that moves basic technologies rapidly from "benchtop to bedside." For more information visit http://www.bli.uci.edu.
CALIFORNIA INSTITUTE FOR TELECOMMUNICATIONS AND INFORMATION TECHNOLOGY (CALIT2)
Calit2 is a two-campus multidisciplinary research institute established by the State of California in 2000. One of four University of California Institutes for Science and Innovation, Calit2 is a partnership between academia and the business community. The Institute's unique research approach integrates academic intellectual capital across a wide range of disciplines with industry expertise. In collaboration with its sister division at UC San Diego, Calit2@UCI seeks innovative IT approaches that will benefit society and ignite economic development in the state and throughout the country.
More than 150 UCI faculty, 250 students, and 100 industry partners are actively engaged in Calit2 research areas that include the environment, transportation, emergency management, health care, education, and entertainment.
Calit2 also strives to prepare students for successful careers after graduation; the Institute's programs include SURF-IT, a summer undergraduate opportunity that immerses students in hands-on research, as well as a graduate fellows program that helps fund a select group of students doing multidisciplinary, IT-focused graduate work. For more information visit http://www.calit2.net/.
CENTER FOR HEALTH POLICY RESEARCH
The Center for Health Policy Research (CHPR) is an interdisciplinary faculty research organization dedicated to improving the quality of care and reducing the disparities in health care. Through research, its faculty and associates translate scientific findings into practice by uniting clinical sciences with the social and behavioral science fields of economics, psychology, anthropology, sociology, and business. This unique platform provides the basis for CHPR's research results to directly effect health policy and the health of the local community and the public.
CHPR is experiencing dramatic growth in personnel, grant support, and achievements, and is committed to building the Center into a nationally recognized focal point for health care research. CHPR has four principal functions: (1) to produce high-level health policy research in the areas of quality of chronic disease care (i.e., diabetes, cancer, nursing home care) and reduce health disparities and improve quality of care for ethnic minorities; (2) to disseminate research findings to UCI's faculty and students through seminar series, meetings, and publications; (3) to serve as the research center for UCI graduate and undergraduate students who have health interests; and (4) to support improvements in patient health and safety and organizational improvements in the UCI health care system.
CHPR's achievement of these goals begins with its facultyan interdisciplinary group of national leaders representing health services research, health economics, clinical epidemiology, psychometrics, and behavioral sciences in medicine. The current research led by CHPR's members and its campuswide collaborators enhance UCI as one of the best research universities in the country.
INSTITUTE FOR CLINICAL AND TRANSLATIONAL SCIENCE
The Institute for Clinical and Translational Science (ICTS) in the Office of Research is a uniquely transformative, novel, and integrative academic home for clinical and translational science with the resources to train and advance a cadre of well-trained multi- and interdisciplinary investigators and research teams. The Institute facilitates access to innovative research tools and information technologies to promote the application of new knowledge and techniques to patient care. ICTS assists basic, translational, and clinical investigators, community clinicians, clinical practices, networks, professional societies, and industry to develop new professional interactions, programs, and research projects. ICTS fosters a new discipline of clinical and translational science that is much broader and deeper than their separate components. The faculty associated with ICTS are instrumental in supporting students in related advanced degree programs via their grants and other sources of financial support. ICTS consists of several units: Pilot and Collaborative Translational and Clinical Studies; Translational Technologies and Resources; Development of Novel Clinical and Translational Methodologies; Biomedical Informatics (including the Center for Medical Informatics); Design, Biostatistics, and Clinical Research Ethics; Regulatory Knowledge and Support; Participant and Clinical Interactions Resources; Community Engagement; and Research Education, Training, and Career Development. More information is available at http://www.icts.uci.edu/.
REEVE-IRVINE RESEARCH CENTER
The Reeve-Irvine Research Center (RIRC) is a basic science research facility devoted to studying cellular and molecular mechanisms that underlie the response of the nervous system to injury, exploring innate and therapeutic regenerative capabilities and developing treatments for spinal cord injury. RIRC has four principal investigators whose laboratories are located in the Center and whose research focuses on the use of rodent models (rats and mice) and related cell culture systems to study how the spinal cord responds to injury. A major focus is on enhancing the regeneration of damaged nerve fibers (axon regeneration) and on the use of stem cells for cellular replacement therapy. There are also 23 associate investigators whose laboratories are located elsewhere in the University who study the response to injury, neural repair, regeneration, and stem cell biology. Some of the associate investigators also carry out human subjects research focusing on advanced functional imaging techniques, novel rehabilitative strategies including the use of robotics, advanced prosthetics, and associated devices that are capable of recording signals from the nervous system.
There are a number of potential targets for therapy for spinal cord injury, and RIRC scientists address many of these. Importantly, some of the most promising strategies, and the ones that are closest to clinical application, involve interventions during the acute post-injury period (days to weeks after the injury). However promising these strategies are, the Center is committed to the long-term goal of developing treatments to promote nerve regeneration and repair for individuals with chronic injuries, and this is reflected in the research programs of each investigator. More information is available at http://www.reeve.uci.edu/.
SUE AND BILL GROSS STEM CELL RESEARCH CENTER
The vision of UCI's Sue and Bill Gross Stem Cell Research Center (SCRC) is to serve as a nexus for stem cell activities in Southern California, and throughout the state, country, and world, and to move forward the understanding of the basic biology of stem cells and therapies from stem cells. Several goals have been articulated to achieve this vision, including: (1) to expand the number of scientists working in the stem cell arena by providing support in the form of technical expertise and equipment, as well as a "federal free" area in which to undertake human embryonic stem cell (hESC) research; (2) to provide educational opportunities for researchers at all levels, and including corporate, medical, and academic scientists, thereby training the next generation of hESC researchers; (3) to support clinical translation of discoveries at the bench into therapies at the bedside through collaborative projects between researchers, clinicians, and the biotechnology sector; and (4) to engage in community outreach to create a dialogue with the public and other disciplines outside the basic and medical sciences.
Development of SCRC has built upon the campus's long-standing strengths in neuroscience, developmental biology, and pharmacology, and collaborations with several Organized Research Units and Centers such as the Reeve-Irvine Research Center, the Center for Mitochondrial Medicine, the Developmental Biology Center, and the Institute for Genomics and Bioinformatics. These partnerships bring expertise, techniques, and alternative perspectives that provide a strong foundation for the Center.
Faculty associated with the Center already have a depth of expertise in the field of stem cell researchthe Center codirectors are pioneers in the field who have been working with human embryonic stem cells (hESC) for 10 years, and UCI faculty have published over 400 articles on stem cells in the past six years. The number of UCI faculty entering this field is also significant.
The Stem Cell Research Center currently is occupying leased space in the University Research Park adjacent to the campus. In addition to administrative space for the Center, this assignment includes a non-federally-funded Stem Cell Core research facility that is intended to be a regional resource for other academic institutions and for the private sector. This facility has been outfitted with many of the pieces of equipment critical to hESC research.
The establishment of the Core facility also has allowed SCRC to move forward with its educational goals, such as the Stem Cell Short Course (a five-day class on hESC cultivation, covering the basics of stem cell cultivation and handling); receiving a Stem Cell Training Grant supporting eight predoctoral and four postdoctoral scholars; UCI Community outreach through lecture series and Public Outreach through the Patient Advisory Committee, a group representing 10 diseases and disorders, whose mission is to inform the SCRC of patient need, to relay information about UCI stem cell research to patient groups and the public, and to raise support and awareness of the potential benefits of stem cell research to society. Visit http://stemcell.uci.edu/ for more information.
UNIVERSITY OF CALIFORNIA HUMANITIES RESEARCH INSTITUTE
The University of California Humanities Research Institute (UCHRI), located at UCI, is a Multicampus Research Unit of the UC Office of the President. Founded in 1987, UCHRI's distinctive mission is to foster intellectual community, research, and public programs across campus boundaries; mobilize the strength of the University of California humanities faculty as a whole; and promote innovative collaborative and interdisciplinary research among humanities scholars and researchers in disciplines across the social sciences, sciences, technology, and medicine.
Residential research groups, historically at the heart of UCHRI's activities, bring together both UC and non-UC scholars, postdoctoral fellows, and advanced UC graduate students to work in collaboration on interdisciplinary topics of special significance. The groups are expected to communicate their findings following residency to a broader scholarly community or public. UCHRI's facilities for participating scholars include private offices with e-mail and Internet access, multimedia meeting rooms, and a reference library. Furnished apartments are provided by the Institute for use by fellows on an as-needed basis during their residencies. UCHRI also sponsors a wide range of conferences and seminars, as well as workshops and other research projects at all of the UC campuses. Two new programs have just been launched: short-term residencies for groups with pre-existing collaborative projects nearing completion; and partnership projects between UC humanities initiatives and community
organizations. The UCHRI Advisory Committee, comprising a faculty representative from each UC campus, makes decisions on program proposals and fellowship applications.
UCHRI also administers the Kevin Starr Postdoctoral Fellowship in California Studies; the Andrew Vincent White and Florence Wales White Graduate Student Scholarship supporting dissertation research in the humanities or theoretical social sciences and medicine; the UC-University Utrecht faculty collaborative research grants; and the annual summer Seminar in Experimental Critical Theory.
The Institute is engaged in an extensive digital humanities initiative in collaboration with researchers both within and beyond the University of California. Scholars interested in UCHRI programs now apply exclusively online via the Institute's FASTAPPS system, which is being adapted for use by other UC units. Virtual collaborative research environments are being implemented as an adjunct to the residential groups. The HASS Grid, developed by UCHRI with the Center for Information Technology Research in the Interest of Society at UC Berkeley and the San Diego Supercomputing Center at UC San Diego, is a major cyberinfrastructure initiative to strengthen research support for the humanities, arts, and social sciences. UCHRI has also led the development of the Humanities, Arts, Science, and Technology Advanced Collaboratory (HASTAC), a consortium of top-level humanities and science institutions in the U.S. and abroad, dedicated to new and productive partnerships across disciplines in order to create tools and databases that will allow for the production of new kinds of knowledge.
For additional information, contact the University of California Humanities Research Institute, 307 Aldrich Hall, Irvine, CA 92697-3350; (949) 824-8180; email@example.com; http://www.uchri.edu, and http://www.hastac.org.
THESAURUS LINGUAE GRAECAE®
The Thesaurus Linguae Graecae (TLG)® is a research project that was established at UCI in 1972, thanks to a gift by UCI alumna Marianne McDonald. Its goals are to create a comprehensive digital library of Greek literature from antiquity to the present era; to conduct literary research using collected texts; and to apply technological innovation in these endeavors. The TLG® corpus currently contains more than 99 million words of Greek text and essentially all extant texts from Homer to the fall of Byzantium in A.D. 1453. Work is underway to include later periods of Greek literature.
TLG® research activities combine the traditional concerns and methodologies of philological and literary study with the most advanced features of computer technology. Included among current research foci are the identification of ancient Greek literary and documentary materials from various literary-historical periods; the conversion of these materials into digital form using modern methods of text encoding; the enhancement of automated text-correction routines; and the formulation of criteria for the lexical analysis and categorization of the texts in the corpus. The project also has established procedures to facilitate international access to its textual, bibliographical, and lexical resources online at http://www.tlg.uci.edu/.
TLG®'s library holdings enhance those of the UCI Langson Library, and TLG® conferences and scholarly visits afford faculty and students contact with eminent scholars in related fields. The Thesaurus Linguae Graecae® has made UCI a major source of Classics research activity.
Organized Research Units
Organized Research Units (ORUs) normally consist of an inter-departmental group of faculty, students, and other researchers engaged in a continuing program of multidisciplinary or interdisciplinary research, supported by both University and extramural funding. The work of some ORUs is directed toward the solution of complex contemporary problems, while others conduct basic research essential to the understanding of natural or social phenomena or of humanistic ideas and expressions. The following ORUs have been established on the Irvine campus.
CANCER RESEARCH INSTITUTE
The Cancer Research Institute provides leadership and support for researchers working toward understanding and controlling cancer. The Institute serves as a means of focusing, coordinating, and directing efforts of scholars in basic and clinical sciences from several departments in the Schools of Biological Sciences and Medicine. It provides a central source of information concerning cancer-related research, as well as a forum in which basic researchers and clinicians can assess advances that may be of immediate value in the diagnosis and treatment of cancer, and in the detection of chemicals or conditions that cause cancer. Ongoing and projected research activities involve the regulation of cell function, viral carcinogenesis, immunology, and basic molecular processes relevant to cancer. The Cancer Research Institute administers Sprague Hall, a research facility in the Biomedical Research Complex dedicated to cancer and genetics. The Cancer Research Institute serves as the basic science arm of UCI's Chao Family Comprehensive Cancer Center, a National Cancer Institute-designated comprehensive cancer center. Other units of the center include the Chao Family Clinical Cancer Research Center and the Cancer Surveillance Program of Orange County. Additional information is available online at http://www.cri.bio.uci.edu/.
CENTER FOR EMBEDDED COMPUTER SYSTEMS
The Center for Embedded Computer Systems, established as an informal center in 1998, was recognized as an ORU in 2001. The Center provides the organizational and administrative structure for researchers at UCI, UCR, and UCSD to conduct leading-edge interdisciplinary research in embedded systems, develop innovative design methodologies, and promote technology and knowledge transfer for the benefit of the individual and society. The research program focuses on three application domains: (1) Communications, including infotainment, information appliances, multimedia, personal imaging, and wireless; (2) Automotive, including collision avoidance, control/sensors, entertainment, and emergency services; and (3) Medical, including diagnosis, drug delivery, imaging, implanted devices, and monitoring. Additional information is available online at http://www.cecs.uci.edu/.
CENTER FOR THE NEUROBIOLOGY OF LEARNING AND MEMORY
The Center for the Neurobiology of Learning and Memory (CNLM), founded at UCI in 1983, is a multidisciplinary research institute that fosters and supports collaborative research on the brain processes underlying learning and memory. CNLM's research teams consist of faculty, professional and postgraduate researchers, graduate and undergraduate students, and visiting scholars. They investigate the formation, maintenance, and retrieval of memory at several levels of analysisfrom studies of molecular and cellular processes in the brain to studies of memory in animal and human subjects.
Current research projects include investigations of the role of specific genes in memory formation, how neurons organize and communicate to enable learning and memory, the way experience alters the structure and organization of the brain, how we acquire and retrieve short- and long-term memories, and emotional influences on memory formation and retrieval. State-of-the-art techniques, including computer modeling of neural
processes and functional neuroimaging, are used. The Center's basic research has important implications for understanding and treating human memory disorders and the diseases that cause them.
CNLM organizes seminars and colloquia throughout the year, as well as periodic workshops and international conferences for the neuroscience community. In addition, the Center organizes and sponsors programs for local schools and the general community, including public lectures focusing on the research of the Center faculty and on health issues related to brain and memory.
CNLM members include faculty from the UCI Departments of Neurobiology and Behavior, Cognitive Sciences, Anatomy and Neurobiology, Neurology, Pharmacology, and Psychology and Social Behavior, as well as faculty from several other UC campuses, the University of Southern California, the Scripps Research Institute, and the California Institute of Technology. CNLM is located in the Bonney and Qureshey Research Laboratories of the Herklotz Research Facility. Visit http://www.cnlm.uci.edu/ for more information.
CENTER FOR RESEARCH ON INFORMATION TECHNOLOGY AND ORGANIZATIONS
The Center for Research on Information Technology and Organizations (CRITO) is a multidisciplinary Organized Research Unit that conducts theoretical and empirical research into the social and economic impacts of information technology (IT) in organizations and society. CRITO focuses on the management, use, and impact of IT in the emerging global, competitive marketplace and on the policy issues raised by its use. CRITO researchers focus on the management of IT, the IT-enabled enterprise, technology-intensive user environments, and the increasingly global nature of IT use and production.
The CRITO Consortium, within CRITO, is the only NSF-supported Industry-University Cooperative Research Center (I/UCRC) on the UCI campus. Corporate sponsors of the Consortium have included, among others, the Boeing Company, the Department of Defense, IBM Corporation, Intel Corporation, International Data Corporation, and Microsoft.
CRITO and Consortium research projects include: nationwide study of computers and the Internet in the home; nationwide study of e-government; the payoffs from investments in IT; outsourcing and offshoring of IT and IT-enabled services; the impacts of IT on firm and industry organization; the impacts of computing on work groups and collaborations; IT structuring for e-commerce; the effects of IT on training, employee performance, and quality of work life; the global spread of production and use of computers; and the globalization of the Internet and e-commerce. For more information, see http://www.crito.uci.edu.
Faculty from The Paul Merage School of Business, the Donald Bren School of Information and Computer Sciences, the School of Social Sciences, and the Department of Education conduct research through the unit. There are approximately 15 faculty associates and 20 students involved in CRITO and Consortium research.
CENTER FOR THE STUDY OF DEMOCRACY
The Center for the Study of Democracy (CSD) sponsors research and education to enhance our scientific understanding of both the democratic process in established democracies including the United States, as well as in expanding democracy around the world. The Center emphasizes five research programs: (1) Democracy21 focuses on the democratic process in established democracies including the United States, as we enter the new century. This program examines ways to increase the citizens' ability to express their preferences and have these preferences represented within the democratic process; (2) Democratic Transitions/Consolidation supports research on the development of sustainable democracies in Eastern Europe, East Asia, and other new democracies; (3) Social Movements and Collective Action focuses on new forms of citizen participation and the use of collective action to expand the boundaries of democratic action; (4) Race, Ethnicity, and Democracy focuses on the representation and participation of minorities, and the institutional structures that may encourage democratic equality; and (5) Economics of Governance examines the intersection of economic and political worlds; how economic principles inform or should inform policy making and how economic factors enter into political decision making.
UCI's expertise in this area was recognized by the National Science Foundation, which selected UCI as a national center for the training of graduate students on democracy. The educational activities continue through CSD's Democracy Fellows program.
CSD hosts an active lecture program, organizes international research conferences, sponsors faculty research, publishes a research paper series, and facilitates research and teaching on democratic themes. The Center has a multidisciplinary faculty from four UC campuses and is one of the leading university-based programs in America devoted explicitly to the study of democracy. Further information is available at http://www.democ.uci.edu/.
CENTER FOR VIRUS RESEARCH
The primary purpose of the Center for Virus Research is to stimulate significant interaction among UCI virologists and other UCI basic and clinical researchers across many disciplines.
Research on viruses has often provided a biological and technological foundation from which much has been discovered concerning the basic molecular processes of organisms. Indeed, this technology has had enormous impact on other areas. As such, the very foundations of molecular biology owe much to virus research. Virology continues to teach us much about normal and disease processes (including cancer) of living systems not only at the molecular and cellular level, but at the level of whole organisms and their populations as well. Viruses have long provided some of the most useful experimental models for disease, cancer, immunity, and genetic systems of gene control. In addition, viral-based technology is being vigorously pursued and developed in the context of gene therapy and is teaching us much about the control of cellular processes.
With the growing worldwide threat of emerging viral diseases, interest in virus research at all levels has intensified and taken on a new global perspective; thus, there is a need at the international level to become more knowledgeable about viruses and disease. As a consequence, previously separate disciplines such as molecular biology, pathogenesis, evolutionary biology, neurology, and radiological sciences can now be readily linked by virus research. Such research pathways provide a highly interdisciplinary character to the Center for Virus Research at UCI. Visit http://cvr.bio.uci.edu/ for more information.
CRITICAL THEORY INSTITUTE
The Critical Theory Institute (CTI) provides a locus for the conduct and support of collaborative, interdisciplinary research that focuses on the theoretical underpinnings of such fields as history, literature, philosophy, art, anthropology, politics, and cultural studies. CTI's principal function is to create a forum for debate among competing movements in contemporary critical theory. CTI's work encompasses not only the application of theory to data but also a self-reflexive investigation of theoretical presuppositions in order to produce alternative theoretical models, methodologies, and research strategies.
CTI investigates problems according to three- to four-year research projects on announced topics, such as "The Forces of Globalization" (1995-99), "The Futures of Property and Personhood" (1999-2003), and "In Security" (2003-06). Research projects involve collaborations between CTI members and contemporary theorists from around the world. Contributors to each project present lectures in CTI's Irvine Lectures in Critical Theory series. Research programs are concluded with the publication of essay collections in CTI's project series with Columbia University Press. See, for example, "Culture" and the Problem of the Disciplines, edited by John Rowe, and Accelerating Possession, edited by Bill Maurer and Gabriele Schwab.
CTI additionally hosts the annual René Wellek Library Lectures, inaugurated in 1981. Every year, typically in the spring quarter, a distinguished scholar delivers three public lectures on a topic relevant to the field of critical theory. Lecturers have included Gayatri Spivak, Judith Butler, Homi Bhabha, Paul Gilroy, Angela Davis, Achille Mbembe, David Harvey, and Talal Asad. The Wellek Lectures also are published with Columbia University Press in CTI's ongoing series. Other activities sponsored by CTI include workshops, conferences, reading and discussion groups, one-time lectures by international scholars, and co-sponsorship of a number of other theory-related events.
In recent years, CTI has established broad connections to distinguished institutions and scholars around the world and has been planning collaborative international projects on a regular basis. The inaugural event, a conference entitled "The States of Theory: China and the West," took place in Beijing in the summer of 2000, and was co-organized by CTI and Beijing Language and Culture University. In April of 2002, CTI hosted another major conference, "Derrida/Deleuze: Psychoanalysis, Territoriality, Politics." The two-day event on connections between Derrida and Deleuze featured keynote lectures by Catherine Malabou and Jacques Derrida, and screenings of "D'Ailleurs Derrida" (Fathy, 2001) and "L'Abécédaire de Gilles Deleuze" (Boutang, 1996). In association with the Postcolonial Institute, CTI participated in another international conference in September 2003 in Melbourne, Australia.
Further information on CTI, including a calendar of events, is available at http://www.humanities.uci.edu/critical.
DEVELOPMENTAL BIOLOGY CENTER
The goal of the research conducted in UCI's Developmental Biology Center (DBC) is to understand the normal processes of development and homeostasis. Development begins with embryogenesis and culminates with formation of an adult animal. Homeostasis refers to the process whereby tissues, such as skin, are continuously rebuilt in adult animals. Abnormal development during embryogenesis is a common cause of birth defects, while abnormal homeostasis is commonly associated with cancer or degenerative disease.
The faculty in the DBC use a wide range of experimental approaches to understand development. The current research areas fall into several themes. These include cancer biology, cell biology, cellular degeneration and regeneration, cellular signaling, growth, patterning and differentiation, and environmental impact.
Advances in research in these areas provide valuable basic information about how development and homeostasis are controlled. This information can then be used to develop tools for diagnosis and treatment of human disease associated with abnormalities in either process.
DBC facilitates this research by providing access to state-of-the-art instrumentation and by fostering events that spur the development of interdisciplinary research. The Center currently provides confocal microscopy, image analysis, flow cytometry and cell sorting, surface plasmon resonance molecular interaction equipment, and robotics. It also sponsors symposia, seminars, and other gatherings to discuss both science itself and implications of the science. Additional information is available at http://dbc.bio.uci.edu/.
GENETIC EPIDEMIOLOGY RESEARCH INSTITUTE
The Genetic Epidemiology Research Institute (GERI) was established in 2004 and brings together scientists from epidemiology, developmental and cell biology, molecular biology and biochemistry, evolutionary biology, genetics, immunology, statistics, bioinformatics, and environmental and behavioral sciences to answer complex questions that can best be explored though an interdisciplinary approach. GERI (1) combines epidemiologic approaches with basic science methods to test hypotheses related to genetic bases of the etiology and progression of disease; (2) facilitates research to apply newly discovered molecular biological processes and genetic characteristics in health and disease in well-characterized human populations; (3) provides epidemiological information that will influence the understanding of the basic processes leading to disease, such as environmental and lifestyle factors, and to test their effect as modifiers of genetic predisposition, thus providing the foundation for disease prevention; and (4) uses advances in information sciences and communication technology to allow for efficient data mining and pattern recognition for genetic epidemiological data.
INSTITUTE FOR BRAIN AGING AND DEMENTIA
The goal of the Institute is to mobilize and unify University resources to discover meaningful ways to prevent decline in brain function with aging prior to its inception and to reverse loss of function once it has occurred. The elusive, yet attainable goal of "successful aging," maintaining functionality in one's later years, is one of the great challenges facing the nation. While many individuals continue to maintain and even improve their intellectual and cognitive skills, others suffer a serious and seemingly irreversible loss of cognitive function and develop dementias, most commonly Alzheimer's disease. The Institute is a fully integrated basic science/clinical research program that operates a Dementia Assessment and Treatment Clinic; a Brain Imaging Acquisition/Analysis Unit; a Tissue Repository for cellular and molecular analysis of the aged and Alzheimer's brain; and a comprehensive database of clinical and research data. Research is multidisciplinary, employing the latest techniques in computer science, artificial intelligence, molecular biology, and neuroscience. The Institute also sponsors a specialized educational track in brain aging and dementia for advanced students who wish to develop a career opportunity in an exciting and expanding field. The Institute is the site of a National Institute on Aging Alzheimer's Disease Research Center and a State of California Department of Health Alzheimer's Disease Research Center.
Faculty from the Departments of Neurobiology and Behavior, Neurology, Radiology, Anatomy and Neurobiology, Molecular Biology and Biochemistry, Microbiology and Molecular Genetics, Cognitive Sciences, and Electrical Engineering and Computer Science; the Donald Bren School of Information and Computer Sciences; and the School of Social Ecology comprise the Institute's core group of investigators.
INSTITUTE FOR GENOMICS AND BIOINFORMATICS
The Institute for Genomics and Bioinformatics (IGB) provides an organizational structure for interdisciplinary research and training in genomics, proteomics, bioinformatics, chemoinformatics, and computational biologyemerging scientific disciplines that are revolutionizing biology, medicine, and society. IGB computational and life scientists are working together to pioneer fundamental processes for reverse engineering gene and protein networks to understand complex biological systems. Through these interdisciplinary collaborations, IGB scientists are creating new theoretical, algorithmic, and software advances in storing, retrieving, networking, processing, modeling, analyzing, navigating, and
visualizing biological information. In turn, their computational and computer science accomplishments are providing methods, predictions, and new hypotheses that are driving biological research in previously unanticipated ways. This scientific cross-fertilization is enriching both fields and will continue to do so in the coming decades. More complete descriptions of the Institute's research and training programs are available at http://www.igbuci.edu/.
INSTITUTE OF GEOPHYSICS AND PLANETARY PHYSICS
The Irvine branch of the Institute of Geophysics and Planetary Physics (IGPP) was established in 2001. IGPP is a University of California Multicampus Research Unit (MRU) established in 1946, with existing branches at UCLA, UCSD, UCR, UCSC, and the Los Alamos and Livermore National Laboratories. The Institute's mission is to promote and coordinate basic research on the understanding of the origin, structure, and evolution of the Earth, the Solar System, and the Universe, and on the prediction of future changes, as they affect human life. The UCI branch's research goals complement the MRU in that the understanding of the Earth as a coupled system of atmosphere, land, and ocean is required to plausibly predict future changes in the Earth System. In order to assess the role of human activities on present and future changes in the global environment, as well as the consequent effects on human life, the UCI branch intends to forge links to other UC campuses as well as the national laboratories. The core of the UCI branch is the Center for Global Environmental Change Research (CGECR), which was established in 1999.
IGPP promotes research at UCI by (1) supporting major research initiatives and facilities jointly with the School of Physical Sciences and the Department of Earth System Science; (2) by supporting research by graduate students; and (3) by supporting visiting scientists, seminars, and workshops that promote collaborative research. Facilities that receive IGPP support include the W. M. Keck Carbon Cycle Accelerator Mass Spectrometry Facility, the Stable Isotope in Atmospheric Trace Gas Facility, the Earth System Modeling Facility, and the Earth System Science (ESS) Analytical Mass Spectronomy Facility.
INSTITUTE FOR MATHEMATICAL BEHAVIORAL SCIENCES
The Institute for Mathematical Behavioral Sciences fosters research in the application of mathematical models and methods to describe and to better understand human behavior, both individual and social. Mimicking the successful interaction between mathematics and the physical sciences, a goal of the Institute is to generate successful interactions between mathematics and the behavioral and social sciences. The Institute sponsors specialized seminars and colloquia, a visiting scholars program, workshops, and focused research groups of faculty, students, and visitors, and it maintains a Technical Report Series. Participants include faculty from the Departments of Anthropology, Cognitive Sciences, Economics, Logic and Philosophy of Science, Political Science, and Sociology in the School of Social Sciences; the Department of Mathematics in the School of Physical Sciences; the Department of Electrical Engineering and Computer Science in The Henry Samueli School of Engineering; the Donald Bren School of Information and Computer Sciences; and The Paul Merage School of Business. Additional information is available at http://www.imbs.uci.edu.
INSTITUTE FOR SOFTWARE RESEARCH
The mission of the Institute for Software Research (ISR) is to advance software and information technology through research partnerships. ISR is dedicated to fostering innovative basic and applied research in software and information technologies. To achieve this goal, ISR works with established companies, start-ups, government agencies, and standards bodies to develop and transition technologies to widespread and practical application. The Institute also focuses on educating the next generation of software researchers and practitioners in advanced software technologies. It supports the public service mission of the University of California in developing the economic basis of the State of California.
Technical emphases of the Institute include software architecture, decentralized development and applications, event-based systems, open-source software development, game culture and technology, software processes, computer-supported cooperative work, human-computer interaction, user interface software, information visualization, privacy and security, ubiquitous computing, software understanding, requirements engineering, analysis and testing, extensible systems, configuration management, configurable distributed systems, Internet protocols and standards, and software engineering education.
Faculty members are drawn from throughout the University of California. Graduate research assistants, professional research staff, and visiting researchers complete the Institute's research body.
ISR supports research projects, sponsors professional meetings, and develops technology. To further its research agenda, the Institute sponsors a distinguished speaker series, technical roundtables, workshops, symposia, and special events. Effective partnerships with industry are essential for ISR to achieve its goals of technology development and transition. Corporate and institutional sponsorships support ISR's research, activities, and professional meetings.
Additional information is available at http://www.isr.uci.edu/.
INSTITUTE FOR SURFACE AND INTERFACE SCIENCE
The detailed understanding, control, and application of phenomena that occur at surfaces and interfaces requires expertise that cuts across the traditional boundaries of science and engineering. The increased activity in the nanosciences provides an excellent example. As structure sizes are reduced into the nanometer regime, the properties of surfaces and interfaces become dramatically more important as the surface-to-volume ratio increases. In this burgeoning new field, new understanding of surface chemistry becomes ever more important to the controlled synthesis of structures (e.g., wires, tubes, particles), new understanding of physics of surfaces and interfaces is required to understand and control the properties, and new engineering approaches are required to convert such structures into a broad range of new devices. The Institute for Surface and Interface Science (ISIS) at UCI exists to stimulate and foster scientific interactions between member faculty who share a common interest in molecular and atomistic-scale understanding and control of phenomena that occur on or at the interfaces between one or more phases of matter. A fundamental understanding of surfaces and interfaces provides a foundation for control of a myriad of technologically important phenomena including: lubrication, catalysis, corrosion, chemical sensing, semiconductor-based electronics, power generation in batteries, fuel cells, and solar cells. ISIS faculty have a diversity of training, experience, and research focuses related to surfaces and interfaces; interactions between members can be highly synergistic, and these interactions make possible a "vertically integrated" treatment of complex problems encompassing theory, fundamental experiments, engineering, and application.
INSTITUTE OF TRANSPORTATION STUDIES
The Institute of Transportation Studies (ITS), a University of California Multicampus Organized Research Unit with branches at Irvine, Davis, and Berkeley, was established by act of the State Legislature in 1947 to foster interdisciplinary research on contemporary transportation issues.
ITS research at UCI involves faculty and students from The Henry Samueli School of Engineering, the School of Social Sciences, the School of Social Ecology, The Paul Merage School of Business, and the Donald Bren School of Information and Computer Sciences.
ITS has a long and rich history of providing both direct and indirect support to the UCI transportation graduate programs. It provides office and research space to virtually all of the students enrolled in UCI's four graduate transportation programsthe interdisciplinary Program in Transportation Science; the graduate concentration in Transportation Economics; the Transportation Planning option in the Department of Planning, Policy, and Design; and the Transportation Systems Engineering graduate focus in the Department of Civil and Environmental Engineering. ITS provides extensive computing resources to all of these students, together with state-of-the art simulation and laboratory facilities. ITS subscribes to the major transportation research journals and offers a variety of computer-based information retrieval services.
Research at ITS covers a broad spectrum of transportation issues. Much of the research conducted by the Institute is organized around centers. The Institute is part of the University of California Transportation Center (UCTC), a federally designated center for transportation research that focuses on research in transportations systems and policy. The ITS Center for Activity Systems Analysis (CASA) supports research directed toward the development of activity-based approaches to travel behavior analysis. For more than 25 years, CASA research associates have been on the leading edge of research in travel demand analysis, establishing an international reputation in the study of complex travel behavior, activity-based approaches, agent-based models, microsimulation approaches, data collection technologies, and empirical modeling. The ITS Center for Advanced Transportation Management Systems Research, which is part of the Universitywide PATH (Partners for Advanced Transit and Highways) program, supports research directed toward the development of intelligent transportation systems. The ITS Advanced Transportation Management Systems (ATMS) Laboratories provide facilities for the teaching, research, and development of intelligent transportation systems. This major effort is complemented by the ITS Center for Traffic Simulation Studies (CTSS), which features prototype systems for modeling and evaluating intelligent transportation systems and telematics. The Center for Logistical Innovations in Freight Systems (CLIFS) focuses on the development of optimization techniques for dynamic and stochastic freight and fleet management and investigation of the impacts of information technology on logistics operations. The Center for Urban Infrastructure (CUI) organizes and conducts research into the role of transportation in achieving and promoting sustainable community development. The Institute also plays a major role in the intelligent transportation and telematics research component of the California Institute for Telecommunications and Information Technology (Calit2), one of the Institutes for Science and Innovation created by the Governor of California.
In addition to projects connected to these centers, ITS researchers are involved in many individual projects across several disciplines. ITS also hosts visiting scholars from the U.S. and abroad to facilitate cooperative research and information exchange, and sponsors conferences and colloquia to disseminate research results.
A Campus Center provides a group of researchers with use of the "Center" title and a structure for its collaborative activities. The rationale for establishing a Campus Center may include attracting greater recognition and extramural support for a research program at UCI and/or providing an infrastructure that promotes synergistic interactions between a group of researchers within a school or across schools. Directors of campus centers typically report to the Dean of their respective schools. More information about the following Campus Centers may be found by clicking on the "Research Centers and Institutes" link at http://www.research.uci.edu/.
Center for Asian Studies
Center for Biomembrance Systems
Center for Demographic and Social Analysis
Center for Diabetes Research and Treatment
Center for Ethnography
Center for Global Peace and Conflict Studies
Center for Hearing Research
Center for Immunology
Center for Learning through the Arts
Center for Organizational Research
Center for Pervasive Communications and Computing
Center for Research on Immigration, Population, and Public Policy
Center for Unconventional Security Affairs
Center in Law, Society and Culture
Center on Inequality and Social Justice
Epilepsy Research Center
International Center for Writing and Translation
Newkirk Center for Science and Society
Tu and Yuen Center for Functional Onco-Imaging
UCI Interdisciplinary Center for the Scientific Study of Ethics and Morality
Urban Water Research Center