DEPARTMENT OF BIOMEDICAL ENGINEERING

3120 Natural Sciences II; (949) 824-9196
http://www.eng.uci.edu/dept/bme
Abraham Lee, Department Chair

Faculty / Undergraduate Program / Graduate Program / Courses

Biomedical engineering combines engineering expertise with medical needs for the enhancement of health care. It is a branch of engineering in which knowledge and skills are developed and applied to define and solve problems in biology and medicine. Students choose the biomedical engineering field to be of service to people, for the excitement of working with living systems, and to apply advanced technology to the complex problems of medical care. Biomedical engineers may be called upon to design instruments and devices, to bring together knowledge from many sources to develop new procedures, or to carry out research to acquire knowledge needed to solve new problems.

During the last 20 years, we have witnessed unprecedented advances in engineering, medical care, and the life sciences. The combination of exploding knowledge and technology in biology, medicine, the physical sciences, and engineering, coupled with the changes in the way health care will be delivered in the next century, provide a fertile ground for biomedical engineering. Biomedical engineering, at the confluence of these fields, has played a vital role in this progress. Traditionally, engineers have been concerned with inanimate materials, devices, and systems, while life scientists have investigated biological structure and function. Biomedical engineers integrate these disciplines in a unique way, combining the methodologies of the physical sciences and engineering with the study of biological and medical problems. The collaboration between engineers, physicians, biologists, and physical scientists is an integral part of this endeavor and has produced many important discoveries in the areas of artificial organs, artificial implants, and diagnostic equipment.

The Department offers a B.S. degree in Biomedical Engineering, a four-year engineering curriculum accredited by the Engineering Accreditation Commission of ABET, 111 Market Place, Suite 1050, Baltimore, MD 21202-4012, telephone (410) 347-7700. This program prepares students for a wide variety of careers in Biomedical Engineering in industry, hospitals, and research laboratories or for further education in graduate school.

The Department also offers a B.S. degree in Biomedical Engineering: Premedical, a four-year engineering curriculum taken with required premedical courses. It is one of many majors that can serve as preparation for further training in medical, veterinary, or allied health professions. It is also suitable for students interested in pursuing graduate work in Biomedical Engineering and other biomedical areas such as physiology, neurosciences, and bioinformatics. The curriculum has less engineering content but more biological sciences than the Biomedical Engineering major. The undergraduate major in Biomedical Engineering: Premedical is not designed to be accredited, therefore is not accredited by ABET.

Areas of graduate study and research include biophotonics, biomedical nanoscale systems, biomedical computational technologies, and tissue engineering.

Undergraduate Major in Biomedical Engineering

Program Educational Objectives: Graduates of the Biomedical Engineering Program will (1) promote continuous improvement in the field of biomedical engineering; (2) communicate effectively the relevant biomedical engineering problem to be solved across the engineering, life science, and medical disciplines; (3) apply critical reasoning as well as quantitative and design skills to identify and solve problems in biomedical engineering; (4) lead and manage biomedical engineering projects in industry, government, or academia that involve multidisciplinary team members. (Program educational objectives are those aspects of engineering that help shape the curriculum; achievement of these objectives is a shared responsibility between the student and UCI.)

Biomedical Engineering students learn engineering and principles of biology, physiology, chemistry, and physics. They may go on to design devices to diagnose and treat disease, engineer tissues to repair wounds, develop cutting-edge genetic treatments, or create computer programs to understand how the human body works.

The curriculum emphasizes education in the fundamentals of engineering sciences that form the common basis of all engineering subspecialties. Education with this focus is intended to provide students with a solid engineering foundation for a career in which engineering practice may change rapidly. In addition, elements of bioengineering design are incorporated at every level in the curriculum. This is accomplished by integration of laboratory experimentation, computer applications, and exposure to real bioengineering problems throughout the program. Students also work as teams in senior design project courses to solve multidisciplinary problems suggested by industrial and clinical experience.

NOTE: Students may complete only one of the following programs: the major in Biomedical Engineering, the major in Biomedical Engineering: Premedical, or the minor in Biomedical Engineering.

ADMISSIONS

High School Students: See page 197.

Transfer Students. Preference will be given to junior-level applicants with the highest grades overall, and who have satisfactorily completed the following required courses: one year of approved calculus, one year of calculus-based physics with laboratories (mechanics, electricity and magnetism), one year of chemistry (with laboratory), and one additional approved course for the major.

Students are encouraged to complete as many of the lower-division degree requirements as possible prior to transfer. Students who enroll at UCI in need of completing lower-division course work may find that it will take longer than two years to complete their degrees. For further information, contact The Henry Samueli School of Engineering at (949) 824-4334.

REQUIREMENTS FOR THE B.S. DEGREE IN BIOMEDICAL ENGINEERING

University Requirements: See pages 54-61.

School Requirements: See page 198.

Major Requirements

Mathematics and Basic Science Courses: Students must complete a minimum of 48 units of mathematics and basic sciences including:

   Core Courses: Mathematics 2A-B, 2D, 3A, 3D, 2E, and Statistics 8; Chemistry 1A-B-C and 1LC; Physics 7C, 7LC; Physics 7D-E, 7LD; Biological Sciences 194S.

Engineering Topics Courses: Students must complete a minimum of 28 units of engineering design including:

   Core Courses: BME1, BME50A-B, BME60A-B-C, BME110A-B-C, BME111, BME120, BME121, BME130, BME140, BME150, BME160, BME170, BME180A-B-C.

   Engineering Electives: Students select, with the approval of a faculty advisor a minimum of 12 units of engineering topics needed to satisfy school and major requirements.

(The nominal Biomedical Engineering program will require 186 units of courses to satisfy all university and major requirements. Because each student comes to UCI with a different level of preparation, the actual number of units will vary).

Engineering Professional Topics Course: ENGR190W.

Optional Specialization in Biophotonics: requires BME135, BME136, and either BME137 or EECS180A. These courses will also satisfy the Engineering Electives requirement.

Optional Specialization in Micro and Nano Biomedical Engineering: requires one course from BME145 or EECS179; and two courses from BME146, BME147, or BME148. These courses will also satisfy the Engineering Electives requirement.

PLANNING A PROGRAM OF STUDY

The sample program of study chart shown is typical for the major in Biomedical Engineering. Students should keep in mind that this program is based upon a sequence of prerequisites, beginning with adequate preparation in high school mathematics, physics, and chemistry. Students who are not adequately prepared, or who wish to make changes in the sequence for other reasons, must have their program approved by their faculty advisor. Biomedical Engineering majors must consult at least once every year with the academic counselors in the Student Affairs Office and with their faculty advisors.

Sample Program of Study - Biomedical Engineering

FALL

WINTER

SPRING

Freshman

Mathematics 2A

Mathematics 2B

Mathematics 2D

Chemistry 1A

Chemistry 1B

Chemistry 1C, 1LC

BME1

Physics 7C, 7LC

Physics 7D, 7LD

General Education

General Education

Sophomore

Mathematics 3A

Mathematics 3D

Mathematics 2E

Physics 7E

BME50A

Statistics 8

BME60A

BME60B

BME50B

General Education

BME60C

Junior

BME110A

BME110B

BME110C

BME120

BME121

BME111

BME130

BME140

BME150

ENGR190W

General Education

Bio. Sci. 194S

General Education

Senior

BME160

BME180B

BME170

BME180A

Engineering Elective

BME 180C

Engineering Elective

General Education

Engineering Elective

General Education

General Education

General Education

Undergraduate Major in Biomedical Engineering: Premedical

The major program objective is to prepare students for medical school. The curriculum is designed to meet the requirements for admission to medical schools, but is also suitable for those planning to enter graduate school in biomedical engineering, physiology, biology, neurosciences, or related fields. It has less engineering content and more biological sciences than the accompanying Biomedical Engineering major. It is one of many majors that can serve as preparation for further training in medical, veterinary, or allied health professions.

The Biomedical Engineering: Premedical curriculum provides future physicians with a quantitative background in biomechanics, bioelectronics, and biotransport. Such a background is increasingly important because of the heavy utilization of biomedical technology in modern medical practice. The curriculum includes courses in the sciences that satisfy the requirements of most medical schools. The education experience is enriched through a design course where students work as teams to solve Biomedical Engineering problems inspired by the clinical arena at the UCI Medical Center.

ADMISSIONS

High School Students: See page 197.

Transfer Students. Preference will be given to junior-level applicants with the highest grades overall, and who have satisfactorily completed the following required courses: one year of approved calculus, one year of calculus-based physics with laboratories (mechanics, electricity and magnetism), one year of chemistry (with laboratory), and one additional approved course for the major.

Students are encouraged to complete as many of the lower-division degree requirements as possible prior to transfer. Students who enroll at UCI in need of completing lower-division course work may find that it will take longer than two years to complete their degrees. For further information, contact The Henry Samueli School of Engineering at (949) 824-4334.

REQUIREMENTS FOR THE B.S. DEGREE IN BIOMEDICAL ENGINEERING: PREMEDICAL

University Requirements: See pages 54-61.

School Requirements: See page 198.

Major Requirements

Mathematics and Basic Science Courses: Students must complete a minimum of 48 units of mathematics and basic sciences including: Mathematics 2A-B, 2D, 3A, and 3D; Chemistry 1A-B-C, 1LC-LD, 51A-B-C, and 51LB-LC; Physics 7C, 7LC; Physics 7D-E and 7LD. Students select, with the approval of a faculty advisor, any additional basic science course needed to satisfy school and major requirements.

Engineering Topics Courses: Students must complete the following engineering topics including: Biological Sciences 97, 98, 99, D103 or D104, 100, D111L, two from E112L or M114L or M116L, 194S; BME1, BME60A-B-C, BME110A-B, BME111, BME120, BME121, BME130, BME150, BME160. Students select, with the approval of a faculty advisor, at least three additional engineering topics courses needed to satisfy school and major requirements.

(The nominal Biomedical Engineering: Premedical program will require 193 units of courses to satisfy all university and major requirements. Because each student comes to UCI with a different level of preparation, the actual number of units will vary).

PLANNING A PROGRAM OF STUDY

The sample program of study chart shown is typical for the major in Biomedical Engineering: Premedical. Students should keep in mind that this program is based upon a sequence of prerequisites, beginning with adequate preparation in high school mathematics, physics, and chemistry. Students who are not adequately prepared, or who wish to make changes in the sequence for other reasons, must have their program approved by their faculty advisor. Biomedical Engineering: Premedical majors must consult at least once every year with the academic counselors in the Student Affairs Office and with their faculty advisors.

Sample Program of Study -Biomedical Engineering: Premedical

FALL

WINTER

SPRING

Freshman

Mathematics 2A

Mathematics 2B

Mathematics 2D

Chemistry 1A

Chemistry 1B

Chemistry 1C, 1LC

BME1

Physics 7C, 7LC

Physics 7D, 7LD

General Education

General Education

Sophomore

Mathematics 3A

Mathematics 3D

Chemistry 51C, 51LC

Chemistry 1LD

Chemistry 51B, 51LB

BME60C

Chemistry 51A

BME60B

General Education

Physics 7E

General Education

General Education

BME60A

Junior

Bio. Sci. 97

Bio. Sci. 98

Bio. Sci. 99

BME110A

BME110B

BME111

BME120

BME121

BME150

BME130

Engineering Elective

General Education

Senior

Bio. Sci. 100

Bio. Sci. D103 or D104

Two from Bio. Sci.
E112L, M114L, M116L

Bio. Sci. 194S

Bio. Sci. D111L

Engineering Elective

BME160

Engineering Elective

General Education

General Education

General Education

MINOR IN BIOMEDICAL ENGINEERING

The minor in Biomedical Engineering requires a total of nine courses—two advanced mathematics courses, five core Biomedical Engineering courses, and two Biomedical Engineering electives. Some of these courses may include prerequisites that may or may not be part of a student's course requirements for their major. Private biomedical industry has indicated a keen interest in engineers that have a more traditional engineering degree (i.e., electrical engineering), but also possess some in-depth knowledge of biomedical systems. Hence, the minor in Biomedical Engineering is designed to provide a student with the introductory skills necessary to perform as an engineer in the biomedical arena.

Admissions. Students interested in the minor in Biomedical Engineering must have a UCI cumulative GPA of 2.5 or higher.

NOTE: Students may not receive both a minor in Biomedical Engineering and a specialization in Biochemical Engineering within the Chemical Engineering major.

Requirements for the Minor in Biomedical Engineering

Mathematics Courses: Mathematics 3A, 3D.

Engineering Topics Courses: BME1, BME50A-B, BME120, BME121.

Technical Electives: Students select, with the approval of a faculty advisor, two technical elective courses: BME110A, BME110B, BME130, BME135 (same as Biological Sciences D130), BME136, BME140, BME160, BME199, CBEMS124, CBEMS126, CBEMS154, EECS179, EECS188.

Graduate Study in Biomedical Engineering

The Biomedical Engineering faculty have special interest and expertise in four thrust areas: Biophotonics, Biomedical Nanoscale Systems, Biomedical Computational Technologies, and Tissue Engineering. Biophotonics faculty are interested in photomedicine, laser microscopy, optical coherence tomography, medical imaging, and phototherapy. Biomedical Nanoscale Systems faculty are interested in molecular engineering, polymer chemistry, molecular motors, design and fabrication of microelectromechanical systems (MEMS), integrated microsystems to study intercellular signaling, and single molecule studies of protein dynamics. Biomedical Computation faculty are interested in computational biology, biomedical signal and image processing, bioinformatics, computational methods in protein engineering, and data mining.

The Department offers the M.S. and Ph.D. degrees in Biomedical Engineering.

Required Background

Because of its interdisciplinary nature, biomedical engineering attracts students with a variety of backgrounds. Thus, the requirements for admission are tailored to students who have a bachelor's degree in an engineering, physical science, or biological science discipline, with a grade point average of 3.20 or higher in their upper-division course work. The minimum course work requirements for admission are six quarters of calculus through linear algebra and ordinary differential equations, three quarters of calculus-based physics, three quarters of chemistry, and two quarters of biology. Students without a physics, chemistry, or engineering undergraduate degree may be required to take additional relevant undergraduate engineering courses during their first year in the program; any such requirements will be specifically determined by the BME Graduate Committee on a case-by-case basis and will be made known to the applicant at the time of acceptance to the program.

The recommended minimum combined verbal and quantitative portion of the GRE is 255, or a minimum combined MCAT score in Verbal Reasoning, Physical Sciences, and Biological Sciences problems of 30. A minimum score of 94 on the Test of English as a Foreign Language (TOEFL iBT) is recommended of all international students whose native language is not English. In addition, all applicants must submit three letters of recommendation.

Exceptionally promising UCI undergraduates may apply for admission through The Henry Samueli School of Engineering's accelerated M.S. and M.S./Ph.D. program, however, these students must satisfy the course work and letters of recommendation requirements described above.

Core Requirement

Both the M.S. and Ph.D. degrees require the students to complete 42 course units. These units include six core courses, the BME298 seminar series, two elective courses, and four units of independent research. The core courses cover the basics of cells, tissues, and physiology at the microscopic and macroscopic scale, engineering mathematics, and clinical theory. The core courses are BME210, BME220, BME221, BME230A, BME230B, BME240, and three quarters of BME298.

Elective Requirement

The two elective courses required to fulfill the course requirements for the M.S. and Ph.D. degree are offered within The Henry Samueli School of Engineering and the Schools of Biological Sciences, Physical Sciences, and Medicine. The electives must provide breadth in biomedical engineering, but also provide specific skills necessary to the specific research the student may undertake as part of the degree requirements. The selection of these courses should be based upon approval of the student's faculty advisor. Upper-division undergraduate courses and courses outside of the HSSoE may be selected upon approval of the BME Graduate Advisor.

Areas of Emphasis

Although a student is not required to formally choose a specific research focus area, four research thrust areas have been identified for the program: Biophotonics, Biomedical Nanoscale Systems, Biomedical Computational Technologies, and Tissue Engineering. These areas capitalize on existing strengths within The Henry Samueli School of Engineering and UCI as a whole, interact in a synergistic fashion, and will train biomedical engineers who are in demand in both private industry and academia.

Biophotonics. This research area includes the use of light to probe individual cells and tissues and whole organs for diagnostic and therapeutic purposes. The research areas include both fundamental investigation on the basic mechanisms of light interaction with biological systems and the clinical application of light to treat and diagnose disease. Current and future foci of the faculty are (1) microscope-based optical techniques to manipulate and study cells and organelles; (2) development of optically based technologies for the non-invasive diagnosis of cells and tissues using techniques that include fiber-optic-based sensors, delivery systems, and imaging systems; and (3) development of optically based devices for minimally invasive surgery.

Nanoscale Systems. This class of research areas encompasses the understanding, use, or design of systems that are at the micron or submicron level. Current strengths within The Henry Samueli School of Engineering and the UCI faculty as a whole include biomaterials, micro-electromechanical systems (MEMS), and the design of new biomedical molecules. The focus of biomedical engineering research in this area is the integration of nanoscale systems with the needs of clinical medicine. Projected areas of growth include (1) micro-electromechanical systems (MEMS) for biomedical devices and biofluid assay; (2) programmable DNA/ molecular microchip for sequencing and diagnostics; and (3) biomaterials and self-assembled nanostructures for biosensors and drug delivery.

Biomedical Computational Technologies. Biomedical computational technologies include both advanced computational techniques, as well as advanced biomedical database systems and knowledge-base systems. Computational technologies that will be developed in this research area include (1) methods for biomedical analysis and diagnosis such as physical modeling of light-tissue interactions, atomic-level interactions, image processing, pattern recognition, and machine-learning algorithms; (2) language instruction and platform standardization; and (3) machine-patient interfaces. Areas of research related to biomedical database systems include the development of new technologies which can capture the rich semantics of biomedical information for intelligent reasoning.

Tissue Engineering. The term tissue engineering was officially coined at a National Science Foundation workshop in 1988 to mean "the application of principles and methods of engineering and life sciences toward fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain, or improve tissue function." Tissue engineering draws on experts from chemical engineering, materials science, surgery, genetics, and related disciplines from engineering and the life sciences. Much of the current research in the field involves growing cells in three-dimensional structures instead of in laboratory dishes. For the most part, cells grown in a flat dish tend to behave as individual cells. But grow a cell culture in a three-dimensional structure, and the cells begin to behave as they would in a tissue or organ. Tissue engineers are testing different methods of growing tissue and organ cells in three-dimensional scaffolds that dissolve once the cells reach a certain mass. The hope is that these cell cultures will mature into fully functional tissues and organs.

MASTER OF SCIENCE DEGREE

Students must successfully complete a minimum of 42 units of course work, as listed under "Core Requirement" and "Elective Requirement" above. A maximum of eight M.S. research units (i.e., BME296) may be applied toward the 42-unit requirement.

In addition, the M.S. degree requires conducting a focused research project. Students must select a thesis advisor and complete an original research investigation including a written thesis, and obtain approval of the thesis by a thesis committee. During their research project, students are expected to enroll in at least 12 units of independent research per quarter.

The degree will be granted upon the recommendation of the Chair of the Department of Biomedical Engineering and The Henry Samueli School of Engineering Associate Dean of Student Affairs.

NOTE: Students who entered prior to fall of 2012 should follow the course requirements outlined within the Catalogue of the year they entered. The changes in number of units per course is not intended to change the course requirements for the degree nor to have any impact in the number of courses students are taking.

DOCTOR OF PHILOSOPHY DEGREE

The Ph.D. degree requires the achievement of an original and significant body of research that advances the discipline. Students with a B.S. degree may enter the Ph.D. program directly, provided they meet the background requirements described above. The Graduate Committee will handle applicants on a case-by-case basis, and any specific additional courses required by the student will be made explicit at the time of admission.

Each student will match with a faculty advisor, and an individual program of study is designed by the student and their faculty advisor. Two depth courses are required beyond that of the M.S. degree in preparation for the qualifying examination. Six milestones are required: (1) successful completion of 42 units of course work beyond the bachelor's degree, as listed under "Core Requirement" and "Elective Requirement" above; (2) successful completion of a preliminary examination; (3) establishing an area of specialization by taking two depth courses and three quarters of BME298 during the second year; (4) formal advancement to candidacy by successfully passing the qualifying examination; (5) students in their third or fourth year must present results of their current research in the BME seminar series; and (6) completion of a significant body of original research and the submission of an acceptable written dissertation and its successful oral defense. During their research project, students are expected to enroll in at least 12 units of independent research per quarter.

The preliminary examination will normally be taken at the end of the first year (May). A student must take it within two years of matriculating in the program, and must either have passed all of the core courses or have an M.S. degree in Biomedical Engineering prior to taking the examination. The Preliminary Examination Committee prepares the examination and sets the minimum competency level for continuing on in the Ph.D. program. Students who fail may retake the examination the following year. Students who fail the second attempt will not be allowed to continue in the program. However, they may be eligible to receive a Master's degree upon completion of an original research investigation including a written thesis (refer to Master of Science Degree requirements). In the event a Ph.D. student decides not to continue in the program, the thesis-only option for the M.S. degree will still be enforced. After passing the preliminary examination at the Ph.D. competency level, students will match with a BME faculty advisor and design an individual program of study with their advisor.

Advancement to candidacy must be completed by the end of the summer of the second year following the passing of the preliminary examination. (Special exceptions can be made, but a formal request with justification must be supplied in writing to the BME Graduate Advisor.) The qualifying examination follows campus and The Henry Samueli School of Engineering guidelines and consists of an oral and written presentation of original work completed thus far, and a coherent plan for completing a body of original research. The qualifying examination is presented to the student's graduate advisory committee, which is selected by the student and faculty advisor and must have a minimum of five faculty (including the faculty advisor). Of these five faculty, three must be BME faculty. In addition, one faculty member must have his/her primary appointment outside the Department of Biomedical Engineering. The fifth member must have his/her primary appointment outside of The Henry Samueli School of Engineering.

The Ph.D. is awarded upon submission of an acceptable written dissertation and its successful oral defense. The degree is granted upon the recommendation of the graduate advisory committee and the Dean of Graduate Division. The normative time for completion of the Ph.D. is five years (four years for students who entered with a master's degree). The maximum time permitted is seven years.

GRADUATE PROGRAM IN MATHEMATICAL AND COMPUTATION BIOLOGY

The graduate program in Mathematical and Computational Biology (MCB) is a one-year "gateway" program designed to function in concert with selected department programs, including the Ph.D. in Biomedical Engineering. Detailed information is available online at http://mcsb.bio.uci.edu/ and in the School of Biological Sciences section of the Catalogue.

Courses in Biomedical Engineering

(Schedule of Classes designation: BmE)

UNDERGRADUATE

BME1 Introduction to Biomedical Engineering (3) F. Introduction to the central topics of biomedical engineering. Offers a perspective on bioengineering as a discipline in a seminar format. Principles of problem definition, team design, engineering inventiveness, information access, communication, ethics, and social responsibility are emphasized. (Design units: 1) Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME50A-B Cell and Molecular Engineering (4-4) W, S. Physiological function from a cellular, molecular, and biophysical perspective. Applications to bioengineering design. (Design units: 2-2) BME50A: Biomedical Engineering, Biomedical Engineering: Premedical, and Materials Science Engineering majors have first consideration for enrollment. BME50B: Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME60A Engineering Analysis/Design: Data Acquisition (4) F. Fundamentals of LabVIEW programming, basics of computer-based experimentation, establishing interface between computer and data acquisition instrumentation, signal conditioning basics. Prerequisite: Physics 7D. (Design units: 2) Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME60B Engineering Analysis/Design: Data Analysis (4). W. Overview of MATLAB; numeric, cell, and structure arrays; file management; plotting and model building; solving linear algebraic equations; differential equations; symbolic processing. Corequisite: Mathematics 3D. Prerequisites: BME60A, Mathematics 2J. (Design units: 1) Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME60C Engineering Analysis/Design: Computer-Aided Design (4) S. Introduction to SolidWorks and Computer-Aided Design software; design; analysis; rapid prototyping; visualization and presentation; planning and manufacturing. Prerequisite: BME60B. (Design units: 2) Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME110A-B-C Biomechanics I, II, III (4-4-4) F, W, S. BME110A: Introduction to statics. Rigid bodies, analysis of structures, forces in beams, moments of inertia. Prerequisites: Physics 7D, 7LD, 7E. BME110B: Introduction to dynamics. kinematics of particles, Newton's Second Law, systems of particles, kinematics of rigid bodies, motion in three dimensions. Prerequisite: BME110A. BME110C: Applications of statics and dynamics to biomedical systems. Cellular biomechanics, hemodynamics, circulatory system, respiratory system, muscles and movement, skeletal biomechanics. Applications to bioengineering design. Prerequisite: BME110B. BME110A-B-C must be taken in the same academic year. (Design units: 1-1-1) BME110A: Biomedical Engineering, Biomedical Engineering: Premedical, and Materials Science Engineering majors have first consideration for enrollment. BME110B: Biomedical Engineering, Biomedical Engineering: Premedical, and Materials Science Engineering majors have first consideration for enrollment. BME110C: Biomedical Engineering majors have first consideration for enrollment.

BME111 Design of Biomaterials (4) S. Natural and synthetic polymeric materials. Metal and ceramics implant materials. Materials and surface characterization and design. Wound repair, blood clotting, foreign body response, transplantation biology, biocompatibility of material. Artificial organs and medical devices. Government regulations. Corequisite or prerequisite: BME 50B. (Design units: 3) Biomedical Engineering, Biomedical Engineering: Premedical, and Materials Science Engineering majors have first consideration for enrollment.

BME120 Quantitative Physiology: Sensory Motor Systems (4) F. A quantitative and systems approach to understanding physiological systems. Systems covered include the nervous and musculoskeletal systems. Prerequisite: Mathematics 3D or equivalent, or consent of instructor. Concurrent with BME220. (Design units: 2) Biomedical Engineering, Biomedical Engineering: Premedical, and Materials Science Engineering majors have first consideration for enrollment.

BME121 Quantitative Physiology: Organ Transport Systems (4) W. A quantitative and systems approach to understanding physiological systems. Systems covered include the cardiopulmonary, circulatory, and renal systems. Prerequisite: Mathematics 3D or equivalent, or consent of instructor. Same as CBEMS104. Concurrent with BME221, CBEMS204. (Design units: 1) Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME130 Biomedical Signals and Systems (4) F. Analysis of analog and digital biomedical signals; Fourier series expansions; difference and differential equations; convolutions. System models: discrete-time and continuous-time linear time-invariant systems; Laplace and Fourier transforms. Analysis of signals and systems using computer programs. Prerequisites: Mathematics 3A and 3D; Statistics 8 recommended. (Design units: 1) Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME135 Photomedicine (4). Studies the use of optical and engineering-based systems (laser-based) for diagnosis, treating diseases, manipulation of cells and cell function. Physical, optical, and electro-optical principles are explored regarding molecular, cellular, organ, and organism applications. Prerequisites: Physics 3C or 7D, or EECS12, or consent of instructor. Same as Biological Sciences D130. (Design units: 0) Biomedical Engineering majors have first consideration for enrollment.

BME136 Engineering Optics for Medical Applications (4). Fundamentals of optical systems design, integration, and analysis used in biomedical optics. Design components: light sources, lenses, mirrors, dispersion elements, optical fibers, detectors. Systems integration: microscopy, radiometry, interferometry. Optical system analysis: resolution, modulation transfer function, deconvolution, interference, tissue optics, noise. Prerequisites: BME130, BME135; EECS180 or consent of instructor. Concurrent with BME236. (Design units: 3) Biomedical Engineering majors have first consideration for enrollment.

BME137 Introduction to Biomedical Imaging (4). Introduction to imaging modalities widely used in medicine and biology, including x-ray, computed tomography (CT), nuclear medicine (PET and SPET), ultrasonic imaging, magnetic resonance imaging (MRI), optical tomography, imaging contrast, imaging processing, and complementary nature of the imaging modalities. Prerequisite: BME130, EECS50, or EECS150; or equivalent. (Design units: 1) Biomedical Engineering majors have first consideration for enrollment.

BME140 Design of Biomedical Electronics (4) W. Analog and digital circuits in bioinstrumentation. AC and DC circuit analysis, design and construction of filter and amplifiers using operational amplifier, digitization of signal and data acquisition, bioelectrical signal, design and construction of ECG instrument, bioelectrical signal measurement and analysis. Prerequisites: BME60C and BME130. (Design units: 3) Biomedical Engineering majors have first consideration for enrollment.

BME146 Miniaturization in Biotechnology and Biological Science (4). Introduction of BIOMEMS to engineering and science students. Study of various sensing technique fundamentals. Introduction to various biosensors. Introduction to biological principles using examples; nanomachining and biomimetics. (Design units: 1) Biomedical Engineering majors have first consideration for enrollment.

BME147 Microfluidics and Lab-on-a-Chip (4). Introduction to principles of microfluidics; LOC (Lab-on-a-Chip) device design, fabrication, operation principles for microscale flow transport, biomolecular manipulation/separation/detection, sample preparation; integrated microfluidic technologies for micro total analysis systems (microTAS) and bioassays. Applications introduced: clinical medicine, health monitoring, biotechnology, biodetection. Prerequisites: BME111 and EECS179, or consent of instructor. Concurrent with BME247. (Design units: 1) Biomedical Engineering majors have first consideration for enrollment.

BME148 Microimplants (4). Essential concepts of biomedical implants at the micro scale. Design, fabrication, and applications of several microimplantable devices including cochlear, retinal, neural, and muscular implants. Prerequisites: BME111 and EECS179, or consent of instructor. Concurrent with BME248. (Design units: 1) Biomedical Engineering majors have first consideration for enrollment.

BME150 Biotransport Phenomena (4) S. Fundamentals of heat and mass transfer; similarities in the respective rate equations. Emphasis on practical application of fundamental principles. Prerequisite: Mathematics 3D or equivalent. BME150 and CBEMS125C may not both be taken for credit. (Design units: 1) Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME160 Tissue Engineering (4) F. Quantitative analysis of cell and tissue functions. Emerging developments in stem cell technology, biodegradable scaffolds, growth factors, and others important in developing clinical products. Applications to bioengineering design. Prerequisites: BME50A-B, BME121. (Design units: 2) Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment.

BME170 Biomedical Engineering Laboratory (4) S. Introduction to measurement and analysis of biological systems using engineering tools and techniques. Laboratory experiments involve living systems with emphasis on biophotonics, BIOMEMS, and physiological systems. Labs include Spectroscopy, BIOMEMS Fabrication and Characterization, Priniciples of the Pulse Oximeter, and Neuroengineering. Prerequisites: BME111, BME120, BME121, BME130, BME140. (Design units: 1) Biomedical Engineering majors have first consideration for enrollment.

BME180A-B-C Biomedical Engineering Design (3-3-3) F, W, S. Design strategies, techniques, tools, and protocols commonly encountered in biomedical engineering; clinical experience at the UCI Medical Center and Beckman Laser Institute; industrial design experience in group projects with local biomedical companies; ethics, economic analysis, marketing, and FDA product approval. Prerequisites: BME111, BME120, BME121, BME140. Open only to senior BME majors. In-progress grading. BME180A-B-C must be taken in the same academic year. (Design units: 3-3-3) BME180A-B-C: Biomedical Engineering majors have first consideration for enrollment.

BME195 Special Topics in Biomedical Engineering (1 to 4). Prerequisites vary. May be repeated for credit. (Design units: varies)

BME197 Seminars in Biomedical Engineering (2) F. Presentation of advanced topics and reports of current research efforts in Biomedical Engineering. Prerequisite: senior standing. Concurrent with BME298. (Design units: varies) Biomedical Engineering majors have first consideration for enrollment.

BME199 Individual Study (1 to 4). Independent research conducted in the laboratory of a Biomedical Engineering core faculty member. A formal written report of the research conducted is required at the conclusion of the quarter. Prerequisites: Biological Sciences 194S and consent of instructor. May be taken for a total of eight units. (Design units: varies)

BME199P Individual Study (1 to 4). Supervised independent reading, research, or design for undergraduate Engineering majors. Students taking individual study for design credit are to submit a written paper to the instructor and to the Undergraduate Student Affairs Office in the School of Engineering. Pass/Not Pass only. May be repeated for credit as topics vary. (Design units: varies)

GRADUATE

BME210 Cell and Tissue Engineering (4) F. A biochemical, biophysical, and molecular view of cell biology. Topics include the biochemistry and biophysical properties of cells, the extracellular matrix, biological signal transduction, and principles of engineering new tissues.

BME213 Systems Cell and Developmental Biology (4). Introduces concepts needed to understand cell and developmental biology at the systems level, i.e., how the parts (molecules) work together to create a complex output. Emphasis on using mathematical/computational modeling to expand/modify insights provided by intuition. Same as Developmental and Cell Biology 232.

BME220 Quantitative Physiology: Sensory Motor Systems (4) F. A quantitative and systems approach to understanding physiological systems. Systems covered include the nervous and musculoskeletal systems. Concurrent with BME120.

BME221 Quantitative Physiology: Organ Transport Systems (4) W. A quantitative and systems approach to understanding physiological systems. Systems covered include the cardiopulmonary, circulatory, and renal systems. Same as CBEMS204. Concurrent with BME121 and CBEMS104.

BME230A Applied Engineering Mathematics I (4) F. Analytical techniques applied to engineering problems in transport phenomena, process dynamics and control, and thermodynamics.

BME230B Applied Engineering Mathematics II (4) W. Advanced engineering mathematics for biomedical engineering. Focuses on biomedical system identification. Includes fundamental techniques of model building and testing such as formulation, solution of governing equations (emphasis on basic numerical techniques), sensitivity theory, identifiability theory, and uncertainty analysis.

BME233 Dynamic Systems in Biology and Medicine (4). Introduces elements of system theory and application of these principles to analyze biomedical, chemical, social, and engineering systems. Students use analytical and computational tools to model and analyze various dynamic systems such as population dynamics, Lotka-Volterra equation, and others.

BME234 Neuroimaging Data Analysis (3). Recent techniques for the analysis of anatomical and functional neuroimaging data.

BME236 Engineering Optics for Medical Applications (4). Fundamentals of optical systems design, integration, and analysis used in biomedical optics. Design components: light sources, lenses, mirrors, dispersion elements, optical fibers, detectors. Systems integration: microscopy, radiometry, interferometry. Optical system analysis: resolution, modulation transfer function, deconvolution, interference, tissue optics, noise. Prerequisites: BME130, BME135; EECS180 or consent of instructor. Concurrent with BME136.

BME240 Introduction to Clinical Medicine for Biomedical Engineering (4) S. An introduction to clinical medicine for graduate students in biomedical engineering. Divided between lectures focused on applications of advanced technology to clinical problems and a series of four rotations through the operating room, ICU, interventional radiology/imaging, and endoscopy.

BME247 Microfluidics and Lab-on-a-Chip (4). Introduction to principles of microfluidics; LOC (Lab-on-a-Chip) device design, fabrication, operation principles for microscale flow transport, biomolecular manipulation/separation/detection, sample preparation; integrated microfluidic technologies for micro total analysis systems (microTAS) and bioassays. Applications introduced: clinical medicine, health monitoring, biotechnology, biodetection. Concurrent with BME147. Formerly BME263.

BME248 Microimplants (4). Essential concepts of biomedical implants at the micro scale. Design, fabrication, and applications of several microimplantable devices including cochlear, retinal, neural, and muscular implants. Prerequisites: BME111 and EECS179, or consent of instructor. Concurrent with BME148.

BME261 Biomedical Microdevices I (4). In-depth review of microfabricated devices designed for biological and medical applications. Studies of the design, implementation, manufacturing, and marketing of commercial and research bio-MEMS devices.

BME295 Special Topics in Biomedical Engineering (1 to 4) F, W, S. Prerequisites vary. May be repeated for credit as topics vary.

BME296 Master of Science Thesis Research (1 to 16). Individual research or investigation conducted in the pursuit of preparing and completing the thesis required for the M.S. in Engineering. Prerequisite: consent of instructor. May be repeated for credit.

BME297 Doctor of Philosophy Dissertation Research (1 to 16). Individual research or investigation conducted in the pursuit of preparing and completing the dissertation required for the Ph.D. in Engineering. Prerequisite: consent of instructor. May be repeated for credit.

BME298 Seminars in Biomedical Engineering (2) F, W, S. Presentation of advanced topics and reports of current research efforts in biomedical engineering. Designed for graduate students in the biomedical engineering program. Satisfactory/Unsatisfactory only. May be repeated for credit. Concurrent with BME197.

BME299 Individual Research (1 to 16). Individual research or investigation under the direction of an individual faculty member. Prerequisite: consent of instructor. May be repeated for credit.