3205 Biological Sciences II; (714) 824-6034
Jerry E. Manning, Department Chair
Dana W. Aswad: Regulation of protein function by covalent modification
Barbara K. Burgess: Structure and function of protein-bound [FeS] and [MoFeS] clusters
Michael G. Cumsky: Mitochondrial protein import; regulation of gene expression in yeast
Rowland H. Davis: Regulation of polyamine metabolism in Neurospora crassa
Ellie Ehrenfeld: Replication and host interactions of poliovirus and hepatitis A
Hung Fan: Molecular biology and pathogenesis of mouse and human retroviruses
Charles G. Glabe: Amyloid Aß peptide in Alzheimer's pathogenesis; gamete recognition
Gale A. Granger: Immunology and pathogenesis: Cell-mediated immunity; tumor immunology; cytokine action
Barbara A. Hamkalo: Molecular basis of differential chromatin condensation
Agnes Henschen-Edman: Protein structure, function, post-translational modification; fibrinogen
Christopher C.W. Hughes: Endothelial cells as initiators and targets of immune responses
Anthony A. James: Malaria parasite development; genetic manipulation of insect vectors
Jerry E. Manning: Major surface proteins and their genes in Trypanosoma cruzi
Ricardo Miledi: Neurotransmitter receptors and synaptic functions
Michael B. O'Connor: Control of gene expression and cell-cell communication in development
Timothy F. Osborne: Transcriptional regulation of cholesterol biosynthesis
Thomas L. Poulos: Protein engineering and crystallography
Donald F. Senear: Interactions of proteins and DNA in transcriptional regulation
Andrea J. Tenner: Molecular basis of the enrichment of human leukocyte function
Krishna K. Tewari: Chloroplast DNA: replication and transcription
Sujata Tewari: Neuromolecular mechanisms of alcohol/drug action on the CNS
Luis P. Villarreal: Tissue-specific viral and cellular gene expression; viral vectors
Edward K. Wagner: Herpes simplex virus gene expression during productive and latent infection
Robert C. Warner: Molecular biology of nucleic acids; physical chemistry of macromolecules; mechanisms of genetic recombination
Clifford A. Woolfolk: General microbiology; enzymology
The research interests of faculty in the Department of Molecular Biology and Biochemistry include structure and synthesis of nucleic acids and proteins, regulation, virology, biochemical genetics, gene organization, nucleic acids and proteins, cell and developmental biology, molecular genetics, biomedical genetics, and immunology.
The Department offers graduate study in conjunction with the program in Molecular Biology, Genetics, and Biochemistry, which is described in a previous section. Students admitted into the combined program who select a research advisor in the Department begin following the departmental requirements for the Ph.D. at the beginning of their third year. Participation in an advanced topics seminar series and completion of at least one course per year for three years are expected of all students.
Several faculty in the Department also are members of the graduate program in Protein Engineering, which is described in a previous section.
200A-B-C Research in Molecular Biology and Biochemistry (2 to 12 per quarter) F, W, S. Individual research supervised by a particular professor. See areas of interest listed under Faculty. Prerequisite: consent of instructor.
201A-B-C Seminars in Molecular Biology and Biochemistry (2-2-2) F, W, S. Seminar, two hours. Presentation of research from department laboratories or, when pertinent, of other recent developments. Prerequisite: consent of instructor. Satisfactory/Unsatisfactory only. May be repeated for credit as topics vary.
202A-B-C Tutorial in Molecular Biology and Biochemistry (4-4-4) F, W, S. Tutorials in the area of research of a particular professor which relate current research to the literature. May be conducted as journal clubs. Prerequisite: consent of instructor.
203 Structure and Biosynthesis of Nucleic Acids (4) F. Lecture, three hours. The structure and properties of nucleic acids. The fundamentals of nucleic acid hybridization and recombinant DNA methodology. Replication and rearrangement of DNA. Prerequisites: Biological Sciences 106 and 107 or the equivalent and Chemistry 51A-B-C or the equivalent. (Coordinators, B. Hamkalo and D. Senear)
204 Structure and Biosynthesis of Proteins (4) F. Lecture, three hours. The structure and properties of proteins. Enzymes and their kinetic properties. Mechanisms of the biosynthesis of proteins. Prerequisites: Biological Sciences 98 and 99 or the equivalent and Chemistry 51A-B-C or the equivalent. (Coordinator, R. Bradshaw and L. Vickery)
205 Topics in Viral Gene Expression (4) W. Lecture, three hours. Primary research data on the major DNA and RNA viruses emphasizing strategies of regulation of gene expression. Utilization of viruses as molecular biological tools. Graduate-level knowledge of the biochemistry and molecular biology of macromolecules is required. Prerequisites: Molecular Biology 203 and 204 or the equivalent. (Coordinators, E. Wagner and B. Semler)
206 Eukaryotic Gene Expression: Chromosomal Genes (4) W. Lecture, three hours. Aspects of gene expression including the organization of the eukaryotic nucleus in terms of protein-nucleic acid interaction (i.e., chromatin and chromosome structure); comparisons between prokaryotic and eukaryotic gene expression, the enzymology and regulation of RNA transcription in E. Coli and other prokaryotes. Enzymology of transcription in eukaryotes. Prerequisites: Molecular Biology 203, 204, and 205. (Coordinators, R. Sandri-Goldin and C. Greer)
207 Molecular Genetics (4) S. Lecture, three hours. Recombination, genome organization, and gene expression at the molecular level, with emphasis on genetic analysis. Prerequisites: Molecular Biology 203, 204, 205, and 206. (Coordinator, R. Davis)
208 Metabolic Regulation (4) F. Lecture, three hours. A consideration of the molecular mechanisms responsible for the regulation of metabolite flow. Examples are chosen from organisms ranging from bacteria to mammals and include regulation of enzyme content. Prerequisites: Biological Sciences 106 and 107 or the equivalent and Chemistry 51A-B-C or the equivalent. (Coordinator, S. Arfin)
209 Literature in Protein Engineering (1) F, W, S. Seminar, one hour, discussion, half-hour. Students review current papers in the field of protein engineering and present the ideas contained therein to other students and faculty. May be repeated for credit. Same as Physiology 209 and Engineering BE209.
210A-B Basic Medical Biochemistry (10-10) F, W. Lecture, ten hours. Classical and molecular biochemistry, including structure, function, and biosynthesis of macromolecules; metabolic interrelations and control mechanisms; and biochemical genetics. Application of recent advances in knowledge of molecular bases for cellular function to disease states (diagnosis, prevention, and treatment). Prerequisite: consent of instructor.
211 Chromosome Structure and Function (4) W every third year beginning 1989. Lecture, three hours; demonstration, one hour. Recent concepts of chromosomal function and structure, exposure to modern electronmicroscopic techniques and their interpretation. Prerequisite: consent of instructor. (Coordinators, B. Hamkalo and J. Manning)
214 Biosynthesis of Nucleic Acids (4) F every third year beginning 1985. Lecture, three hours. Structure, function, and replication of DNA and RNA in procaryotes and eucaryotes; emphasis on current research. Prerequisite: consent of instructor. (Coordinator, S. Tewari)
218 Clinical Cancer (3) F of even years. Lecture, two hours. Designed to acquaint students in basic life science with clinical cancer. Restricted to graduate and postdoctoral students. May be repeated for credit. (Coordinator, H. Fan)
221 Advanced Immunology (4) S every third year beginning 1983. Lecture, three hours; discussion, one hour. History, techniques, and concepts of humoral antibody formation and cellular immune patterns. Advanced topics in transplantation and tumor immunobiology. Prerequisite: Biological Sciences 121 or consent of instructor. (Coordinator, G. Granger)
223 Computational Molecular Biology (4) W. Lecture, one hour; laboratory, two hours. The use of computer networks, data bases, and programs in molecular biology. Students choose a protein sequence from DNA sequence data. This sequence is entered, edited, and analyzed following simulated genetic engineering. Prerequisite: consent of instructor. (Coordinator, L. Villarreal)
224 Mechanisms of Viral Transformation (4) F every third year beginning 1989. Lecture, three hours. The molecular mechanisms by which RNA and DNA tumor viruses transform cells. Emphasis on current research papers. Prerequisite: Molecular Biology and Biochemistry 205.
226 Animal Virology (4) S every third year beginning 1986. Lecture, two hours. Elements of viral infection, including the role of viruses as potential oncogenic agents. Prerequisite: consent of instructor. (Coordinator, E. Wagner)
231 Molecular Biology of Fungi (4) S of every third year beginning 1993. Lecture, three hours. Current topics in the molecular biology of filamentous fungi and allied organisms, such as mechanisms of recombination, DNA-mediated transformation, genome organization, metabolic regulatory systems, and mating systems. (Coordinator, R. Davis)
240 Macromolecular Structure, Function, and Interaction (4) F. Lecture, three hours; discussion, one hour. Chemistry of macromolecules; emphasis on proteins. Physical and chemical properties of proteins, forces that maintain protein structure, relationship between structure and function, interactions of proteins with ligands and other macromolecules, and experimental methods to study structure, function, and interactions. Corequisite: Chemistry 130A, 131A, or equivalent. Prerequisites: Molecular Biology 203 and 204. Concurrent with Biological Sciences 140. (Coordinators: D. Senear and T. Poulos)
264 Colloquium in Biophysical Chemistry (2) W. Colloquium, two hours. Presentation of research topics in biophysics and biophysical chemistry. Faculty and invited speakers address the fundamentals and background of physical approaches to biological problems and the experimental results obtained with them. Supplementary reading required. Prerequisites: Chemistry 130A-B-C, Chemistry 131A-B-C, or equivalent. Graduate standing. Satisfactory/ Unsatisfactory Only. Same as Physiology and Biophysics 264 and Chemistry 264. May be repeated for credit.
280 Advanced Topics in Biochemistry and Molecular Biology (3) F. Lecture, five hours. Selected topics in specified areas of concentration, e.g., nucleic acids, protein biochemistry, genetic expression, biochemical genetics. Specific topics announced in advance. Prerequisites: Biological Sciences 106 and 107 and consent of instructor. Normally taken with Molecular Biology and Biochemistry 205A. Open to advanced undergraduates.
290A-B-C Colloquium in Molecular Biology and Biochemistry (2-2-2) F, W, S. Colloquium, one and one-half hours. Contemporary research problems in molecular biology and biochemistry. Invited speakers present research and/or review topics. Satisfactory/Unsatisfactory Only. May be repeated for credit.
399 University Teaching (4-4-4) F, W, S. Limited to Teaching Assistants.
